Publication

Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders

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Last modified
  • 06/25/2025
Type of Material
Authors
    Christina Michalski, Emory UniversityZhexing Wen, Emory University
Language
  • English
Date
  • 2023-11-09
Publisher
  • Frontiers
Publication Version
Copyright Statement
  • © 2023 Michalski and Wen.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 14
Start Page
  • 1291115
Grant/Funding Information
  • The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported in part by the following funding sources: National Institutes of Health (AG065611, AG079256, MH123711, and MH132012 to ZW), Department of Defense (W81XWH1910353 to ZW), and PhRMA Foundation (Postdoctoral Fellowship in Translational Medicine to CM).
Abstract
  • Communication between the immune and the nervous system is essential for human brain development and homeostasis. Disruption of this intricately regulated crosstalk can lead to neurodevelopmental, psychiatric, or neurodegenerative disorders. While animal models have been essential in characterizing the role of neuroimmunity in development and disease, they come with inherent limitations due to species specific differences, particularly with regard to microglia, the major subset of brain resident immune cells. The advent of induced pluripotent stem cell (iPSC) technology now allows the development of clinically relevant models of the central nervous system that adequately reflect human genetic architecture. This article will review recent publications that have leveraged iPSC technology to assess neuro-immune interactions. First, we will discuss the role of environmental stressors such as neurotropic viruses or pro-inflammatory cytokines on neuronal and glial function. Next, we will review how iPSC models can be used to study genetic risk factors in neurological and psychiatric disorders. Lastly, we will evaluate current challenges and future potential for iPSC models in the field of neuroimmunity.
Author Notes
Keywords
Research Categories
  • Biology, Neuroscience
  • Biology, Genetics
  • Health Sciences, Immunology

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