SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activity

• Type of Material: Article
• Authors: Jenna M Antonucci, Ohio State University; Corine St Gelais, Ohio State University; Suresh de Silva, Ohio State University; Jacob S Yount, Ohio State University; Chenxiang Tang, Yale University; Xiaoyun Ji, Yale University; Caitlin Shepard, Emory University; Yong Xiong, Yale University; Baek Kim, Emory University; Li Wu, Ohio State University
• Language: English
• Date: 2016-10-06
• Publisher: Nature Publishing Group
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2016, Springer Nature America, Inc.
• Final Published Version (URL): http://dx.doi.org/10.1038/nm.4163
• Title of Journal or Parent Work: Nature Medicine
• ISSN: 1078-8956
• Volume: 22
• Issue: 10
• Start Page: 1072
• End Page: 1074
• Grant/Funding Information: This work was supported by NIH grants AI104483 and CA181997 (L.W.), AI114826 (J.S.Y.), AI102778 (Y.X.), AI120845 (X.J.) and AI049781 and GM104198 (B.K.).
• Keywords: SAMHD1 RESTRICTS; Medicine, Research & Experimental; Life Sciences & Biomedicine; CD4(+) T-CELLS; Research & Experimental Medicine; PROTEIN; ACTIVATION; NUCLEASE ACTIVITY; Science & Technology; Biochemistry & Molecular Biology; INFECTION; DGTP; Cell Biology; INHIBITION; PHOSPHORYLATION; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE