TTF-1 Expression in Rectal Adenocarcinoma: A Case Report and Review of the Literature

• Type of Material: Article
• Authors: Astrid Belalcazar, Emory University; Walid Shaib, Emory University; Uma Krishnamurti, Emory University
• Language: English
• Date: 2016-11-18
• Publisher: Karger Publishers
• Publication Version: Final Published Version
• Copyright Statement: © 2016 The Author(s). Published by S. Karger AG, Basel.
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1159/000450973
• Title of Journal or Parent Work: Case Reports in Oncology
• ISSN: 1662-6575
• Volume: 9
• Issue: 3
• Start Page: 747
• End Page: 751
• Keywords: TTF; TTF-1; Thyroid transcription factor; Rectal cancer; Rectal adenocarcinoma; Immunohistochemistry; Colorectal cancer; Colorectal adenocarcinoma
• Research Categories: Health Sciences, Pathology; Health Sciences, Oncology

Abstract

Thyroid transcription factor 1 (TTF-1) is considered a highly sensitive and specific marker for primary lung adenocarcinoma. However, in recent years retrospective studies of tumor samples have confirmed that, although rare, TTF-1 can also be expressed in colorectal adenocarcinoma. There are a few case reports of patients with TTF-1-positive colon adenocarcinoma in the medical literature but none of TTF-1-positive rectal adenocarcinoma. Here, we present a case of rectal adenocarcinoma with lung metastasis found to be TTF-1 positive on immunohistochemistry. A review and discussion of the available literature is also included.