Incidence Patterns and Outcomes for Hodgkin Lymphoma Patients in the United States

• Type of Material: Article
• Authors: Pareen Shenoy, Emory University; Alison Maggioncalda, Emory University; Neha Malik, Emory University; Christopher R Flowers, Emory University
• Language: English
• Date: 2010-10-19
• Publisher: Hindawi Publishing Corporation
• Publication Version: Final Published Version
• Copyright Statement: © 2011 Pareen Shenoy et al.
• License: Creative Commons Attribution 3.0 Unported
• Final Published Version (URL): http://www.hindawi.com/journals/ah/2011/725219/
• Title of Journal or Parent Work: Advances in Hematology
• ISSN: 1687-9104
• Volume: 2011
• Issue: 2011
• Start Page: 1
• End Page: 10
• Grant/Funding Information: This work is funded by grants from the American Society of Hematology and the Leukemia & Lymphoma Society.
• Research Categories: Health Sciences, Oncology; Biology, Microbiology

Abstract

Hodgkin lymphoma (HL) demonstrates heterogenous histologic findings, clinical presentation, and outcomes. Using the United States Surveillance, Epidemiology, and End Results (SEER) data we examined relationships between patient characteristics, clinical features at diagnosis, and survival in HL patients. From 2000 to 2007, 16,710 cases were recorded in 17 SEER registries. Blacks and Asians had low incidence (black/white incidence rate ratio (IRR) 0.86, P< .01; Asian/white IRR 0.43, P< .01). The bimodal pattern of incidence was less prominent for black males. Asians and Blacks presented at a mean age of 38 years compared to 42 years for Whites (P< .001). Race was a predictor for survival with HR of 1.19 (95% CI 1.11–1.28) for Blacks. Age was the most important predictor of survival (HR for patients ≥45 years 5.08, 95% CI 4.86–5.31). These current patterns for presentation and outcomes of HL help to delineate key populations in order to explore risk factors for HL and strategies to improve treatment outcomes.