Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis

• Type of Material: Article
• Authors: Jun Chen, University of Alabama Birmingham; Xixi Zhang, University of Alabama Birmingham; Reid Millican, The University of Alabama at Birmingham; Jennifer Sherwood, The University of Alabama at Birmingham; Sean Martin, The University of Alabama at Birmingham; Hanjoong Jo, Emory University; Young Yoon, Emory University; Brigitta C Brott, The University of Alabama at Birmingham; Ho-Wook Jun, The University of Alabama at Birmingham
• Language: English
• Date: 2021-01-23
• Publisher: ELSEVIER
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2021 Elsevier B.V. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.addr.2021.01.005
• Title of Journal or Parent Work: ADVANCED DRUG DELIVERY REVIEWS
• Volume: 170
• Start Page: 142
• End Page: 199
• Keywords: SMOOTH-MUSCLE-CELL; Theranostic agents; Imaging contrast agents; Atherosclerosis; Therapeutic delivery system; Pharmacology & Pharmacy; HYALURONIC-ACID NANOPARTICLES; PLASMONIC PHOTOTHERMAL THERAPY; FOAM CELL-FORMATION; Science & Technology; SUPERPARAMAGNETIC IRON-OXIDE; Life Sciences & Biomedicine; Clinical use; GRAPHENE OXIDE; MEDIATED TARGETED DELIVERY; HIGH-DENSITY-LIPOPROTEIN; Nanomaterials; IN-STENT RESTENOSIS; HDL MIMETIC CER-001

Abstract

Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation in arteries, leading to narrowing and thrombosis. It affects the heart, brain, and peripheral vessels and is the leading cause of mortality in the United States. Researchers have strived to design nanomaterials of various functions, ranging from non-invasive imaging contrast agents, targeted therapeutic delivery systems to multifunctional nanoagents able to target, diagnose, and treat atherosclerosis. Therefore, this review aims to summarize recent progress (2017-now) in the development of nanomaterials and their applications to improve atherosclerosis diagnosis and therapy during the preclinical and clinical stages of the disease.