Stem cells and cell therapy approaches in lung biology and diseases

• Type of Material: Article
• Authors: Viranuj Sueblinvong, Emory University; Daniel J. Weiss, University of Vermont
• Language: English
• Date: 2010-09-01
• Publisher: Elsevier: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2010 Mosby, Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.trsl.2010.06.007
• Title of Journal or Parent Work: Translational Research, The Journal of Laboratory and Clinical Medicine
• ISSN: 1931-5244
• Volume: 156
• Issue: 3
• Start Page: 188
• End Page: 205
• Grant/Funding Information: Research support includes: NHLBI HL087274 (DJW), HL081289 (DJW), research grants from the Cystic Fibrosis Foundation (DJW, VS) and the American Lung Association (DJW), and NCRR COBRE P20 RR-155557 (C Irvin)
• Keywords: Science & Technology; Research & Experimental Medicine; General & Internal Medicine; ALVEOLAR EPITHELIAL-CELLS; Life Sciences & Biomedicine; Medicine, General & Internal; Medical Laboratory Technology; Medicine, Research & Experimental; MARROW-DERIVED CELLS; PULMONARY ARTERIAL-HYPERTENSION; IN-VITRO; ANGIOPOIETIN-1 GENE-THERAPY; MESENCHYMAL STROMAL CELLS; ENDOTHELIAL PROGENITOR CELLS; CFTR-NULL MICE; TISSUE-ENGINEERED LUNG; ADULT BONE-MARROW
• Research Categories: Health Sciences, Medicine and Surgery; Health Sciences, Pathology

Abstract

Cell-based therapies with embryonic or adult stem cells, including induced pluripotent stem cells, have emerged as potential novel approaches for several devastating and otherwise incurable lung diseases, including emphysema, pulmonary fibrosis, pulmonary hypertension, and the acute respiratory distress syndrome. Although initial studies suggested engraftment of exogenously administered stem cells in lung, this is now generally felt to be a rare occurrence of uncertain physiologic significance. However, more recent studies have demonstrated paracrine effects of administered cells, including stimulation of angiogenesis and modulation of local inflammatory and immune responses in mouse lung disease models. Based on these studies and on safety and initial efficacy data from trials of adult stem cells in other diseases, groundbreaking clinical trials of cell-based therapy have been initiated for pulmonary hypertension and for chronic obstructive pulmonary disease. In parallel, the identity and role of endogenous lung progenitor cells in development and in repair from injury and potential contribution as lung cancer stem cells continue to be elucidated. Most recently, novel bioengineering approaches have been applied to develop functional lung tissue ex vivo. Advances in each of these areas will be described in this review with particular reference to animal models.