Trimethoprim-Sulfamethoxazole Prophylaxis and Antibiotic Nonsusceptibility in Invasive Pneumococcal Disease

• Type of Material: Article
• Authors: Heidi M. Soeters, Emory University; Anne von Gottberg, National Institute for Communicable Diseases; Cheryl Cohen, National Institute for Communicable Diseases; Vanessa Quan, National Institute for Communicable Diseases; Keith Klugman, Emory University
• Language: English
• Date: 2012-03-01
• Publisher: American Society for Microbiology
• Publication Version: Final Published Version
• Copyright Statement: Copyright © 2012, American Society for Microbiology. All Rights Reserved.
• Final Published Version (URL): http://dx.doi.org/10.1128/AAC.05813-11
• Title of Journal or Parent Work: Antimicrobial Agents and Chemotherapy
• ISSN: 0066-4804
• Volume: 56
• Issue: 3
• Start Page: 1602
• End Page: 1605
• Grant/Funding Information: The contents of this work are solely the responsibility of the authors and do not necessarily represent the official views of CDC.; This work was supported by the Rollins School of Public Health Global Field Experience Global Frameworks Grant (to H.M.S.); the Rollins School of Public Health Student Initiative Fund (to H.M.S.); the United States Agency for International Development's Antimicrobial Resistance Initiative, transferred via a cooperative agreement (number U60/CCU022088) from the Centers for Disease Control and Prevention (CDC), Atlanta, GA (2003 to 2006); and the CDC, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP), Global AIDS Program (GAP) cooperative agreement U62/PSO022901(2005 to 2007).
• Keywords: STREPTOCOCCUS-PNEUMONIAE; TRIAL; CHILDREN; Life Sciences & Biomedicine; SOUTH-AFRICA; CARRIAGE; Microbiology; MICROBIOLOGY; ANTIRETROVIRAL THERAPY; Pharmacology & Pharmacy; RESISTANCE; IMPACT; HIV; COTRIMOXAZOLE; Science & Technology; PHARMACOLOGY & PHARMACY
• Research Categories: Health Sciences, Pharmacology; Health Sciences, Medicine and Surgery

Abstract

Among 5,043 invasive pneumococcal disease (IPD) isolates identified through South African national surveillance from 2003 to 2007, we estimated the effect of trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis on antimicrobial resistance. Patients on TMP-SMX prophylaxis were more likely to have a pneumococcal isolate nonsusceptible to TMP-SMX, penicillin, and rifampin. TMP-SMX nonsusceptibility was associated with nonsusceptibility to penicillin, erythromycin, and rifampin and multidrug resistance. This study informs empirical treatment of suspected IPD in patients with a history of TMP-SMX use.