North American Prodrome Longitudinal Study (NAPLS 2): Overview and recruitment

• Type of Material: Article
• Authors: Jean Addington, University of Calgary; Kristin S. Cadenhead, University of California San Diego; Barbara A. Cornblatt, Zucker Hillside Hospital; Daniel H. Mathalon, University of California San Francisco; Thomas H. McGlashan, Yale University; Diana O. Perkins, University of North Carolina; Larry J. Seidman, Harvard Medical School at Beth Israel Deaconess Medical Center; Ming T. Tsuang, Zucker Hillside Hospital; Elaine Walker, Emory University; Scott W. Woods, University of California San Francisco; Jack A. Addington, University of Calgary; Tyrone D. Cannon, University of California Los Angeles
• Language: English
• Date: 2012-12
• Publisher: Elsevier
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2012 Elsevier B.V. Published by Elsevier Inc. All rights reserved.
• Final Published Version (URL): http://dx.doi.org/10.1016/j.schres.2012.09.012
• Title of Journal or Parent Work: Schizophrenia Research
• ISSN: 0920-9964
• Volume: 142
• Issue: 1-3
• Start Page: 77
• End Page: 82
• Grant/Funding Information: This study was supported by the National Institute of Mental Health (grant U01MH081984 to Dr Addington; grants U01 MH081928; P50 MH080272; Commonwealth of Massachusetts SCDMH82101008006 to Dr Seidman; grants R01 MH60720, U01 MH082022 and K24 MH76191 to Dr Cadenhead; grant to Dr Cannon; grant U01MH082004-01A1 to Dr Perkins; grant U01MH081988 to Dr Walker; grant U01MH082022 to Dr Woods; and UO1 MH081857-05 grant to Dr Cornblatt.
• Keywords: High risk; Recruitment; Methods; Psychosis
• Research Categories: Psychology, General

Abstract

The North American Prodrome Longitudinal Study (NAPLS) is a consortium of eight programs focusing on the psychosis prodrome. Funded by the National Institute of Mental Health (NIMH), the sites are located at Emory University, Harvard University, University of Calgary, UCLA, UCSD, University of North Carolina Chapel Hill, Yale University, and Zucker Hillside Hospital. Although the programs initially developed independently, they previously collaborated to combine their historical datasets and to produce a series of analyses on predictors of psychosis in one of the largest samples of longitudinally followed prodromal subjects worldwide. This led to the development of a five year prospective study “Predictors and Mechanisms of Conversion to Psychosis”, (also known as NAPLS-2) with three major aims: (1) to prospectively test the prediction algorithm developed in NAPLS-1, (2) to investigate the neuroanatomical, neurophysiological, neurocognitive, and neurohormonal factors that may contribute to the development of psychosis, and (3) to develop a repository of DNA, RNA, and plasma from participants meeting diagnostic criteria for a clinical high risk (CHR) state and from demographically similar healthy subjects. Funded by NIMH in 2008, NAPLS-2 will generate the largest CHR for psychosis sample with 720 CHR and 240 healthy comparison subjects, and thus will provide statistical power and scientific scope that cannot be duplicated by any single site study. This paper describes the overall methodology of the NAPLS-2 project and reports on the ascertainment and demographics at the midway point of the study with (360 CHR) and 180 controls.