Neuropathology of transgenic HD animal models

• Type of Material: Article
• Authors: Xiao-Jiang Li, Emory University; Shi Hua Li, Emory University
• Language: English
• Date: 2012
• Publisher: BMC Publications
• Publication Version: Final Published Version
• Copyright Statement: © 2012 Li and Li; licensee BioMed Central Ltd.
• License: Creative Commons Attribution 2.0 Generic
• Final Published Version (URL): http://dx.doi.org/10.1186/1750-1326-7-S1-L17
• Title of Journal or Parent Work: Molecular Neurodegeneration
• Volume: 7
• Issue: Suppl 1
• Start Page: L17
• End Page: L17
• Grant/Funding Information: None declared
• Keywords: Huntington’s disease; Transgenic HD animal models; Neurodegeneration; Pathogenesis; Neuropathology; Molecular Biology
• Research Categories: Biology, Neuroscience; Biology, Genetics; Biology, Molecular

Abstract

Identification of the polyglutamine expansion in huntingtin (htt) responsible for Huntington disease (HD) has allowed the establishment of a variety of transgenic mouse models of HD. Although these mouse models have been widely used to uncover the pathogenesis of HD and to develop its treatments, most of these mouse models show no overt neurodegeneration in their brains. Similarly, transgenic mouse models for other neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases do not display obvious apoptosis or significant neurodegeneration either.