Recommendations for the surveillance of education and employment outcomes in survivors of childhood, adolescent, and young adult cancer: A report from the International Late Effects of Childhood Cancer Guideline Harmonization Group

• Type of Material: Article
• Authors: Katie A Devine, Rutgers, The State University of New Jersey; Salome Christen, University of Lucerne; Renée L Mulder, Princess Máxima Center for Pediatric Oncology; Morven C Brown, Newcastle University; Lisa Ingerski, Emory University; Luzius Mader, Danish Cancer Society Research Center; Emma J Potter, The Royal Marsden Hospital; Charlotte Sleurs, Katholieke University Leuven; Adrienne S Viola, Rutgers, The State University of New Jersey; Susanna Waern, The Royal Marsden Hospital; Louis S Constine, University of Rochester; Melissa M Hudson, St. Jude Children's Research Hospital; Leontien CM Kremer, Princess Maxima Ctr Pediat Oncol; Roderick Skinner, Newcastle Univ; Gisela Michel, University of Lucerne; Jordan Marchak, Emory University; Fiona SM Schulte, University of Calgary
• Language: English
• Date: 2022-04-18
• Publisher: WILEY
• Publication Version: Final Published Version
• Copyright Statement: © 2022 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society
• License: Creative Commons Attribution-NonCommercial 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1002/cncr.34215
• Title of Journal or Parent Work: CANCER
• Volume: 128
• Issue: 13
• Start Page: 2405
• End Page: 2419
• Grant/Funding Information: This work was supported by the Krebsliga Zentralschweiz, the Swiss National Science Foundation (grants 10001C_182129/1 and 100019_153268/1), and the European Union's Seventh Framework Programme for Research, Technological Development, and Demonstration (grant agreement 257505). The funding sources had no influence on the collection, analysis, or interpretation of the data; on the writing of the manuscript; or on the decision to submit the manuscript for publication.
• Keywords: Oncology; NEUROCOGNITIVE OUTCOMES; ACUTE LYMPHOBLASTIC-LEUKEMIA; education; childhood; adolescent; late effects; FOLLOW-UP; employment; Life Sciences & Biomedicine; STEM-CELL TRANSPLANTATION; Science & Technology; survivorship; GREAT-BRITAIN; evidence-based guidelines; LONG-TERM SURVIVORS; NEUROPSYCHOLOGICAL PERFORMANCE; OCCUPATIONAL OUTCOMES; QUALITY-OF-LIFE; SCHOOL PERFORMANCE; and young adult cancer
• Research Categories: Health Sciences, Oncology; Health Sciences, Medicine and Surgery

Abstract

Educational achievement and employment outcomes are critical indicators of quality of life in survivors of childhood, adolescent, and young adult (CAYA) cancer. This review is aimed at providing an evidence-based clinical practice guideline (CPG) with internationally harmonized recommendations for the surveillance of education and employment outcomes in survivors of CAYA cancer diagnosed before the age of 30 years. The CPG was developed by a multidisciplinary panel under the umbrella of the International Late Effects of Childhood Cancer Guideline Harmonization Group. After evaluating concordances and discordances of 4 existing CPGs, the authors performed a systematic literature search through February 2021. They screened articles for eligibility, assessed quality, and extracted and summarized the data from included articles. The authors formulated recommendations based on the evidence and clinical judgment. There were 3930 articles identified, and 83 of them, originating from 17 countries, were included. On a group level, survivors were more likely to have lower educational achievement and more likely to be unemployed than comparisons. Key risk factors for poor outcomes included receiving a primary diagnosis of a central nervous system tumor and experiencing late effects. The authors recommend that health care providers be aware of the risk of educational and employment problems, implement regular surveillance, and refer survivors to specialists if problems are identified. In conclusion, this review presents a harmonized CPG that aims to facilitate evidence-based care, positively influence education and employment outcomes, and ultimately minimize the burden of disease and treatment-related late adverse effects for survivors of CAYA cancers. Lay Summary: A multidisciplinary panel has developed guidelines for the surveillance of education and employment outcomes among survivors of childhood, adolescent, and young adult cancer. On the basis of evidence showing that survivors are at risk for lower educational achievement and unemployment, it is recommended that all survivors receive regular screening for educational and employment outcomes.