Publication

The Sweet-Side of Leukocytes: Galectins as Master Regulators of Neutrophil Function

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Last modified
  • 05/21/2025
Type of Material
Authors
    Brian Robinson, Emory UniversityConnie Arthur, Emory UniversityBirk Evavold, Emory UniversityEthan Roback, Emory UniversityNourine A. Kamili, Emory UniversityCaleb S. Stowell, Emory UniversityMary L. Vallecillo-Zuniga, Brigham Young UniversityPam M. Van Ry, Brigham Young UniversityMarcelo Dias-Baruffi, University of São PauloRichard Cummings, Emory UniversitySean Stowell, Emory University
Language
  • English
Date
  • 2019-08-07
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2019 Robinson, Arthur, Evavold, Roback, Kamili, Stowell, Vallecillo-Zúniga, Van Ry, Dias-Baruffi, Cummings and Stowell.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-3224
Volume
  • 10
Start Page
  • 1762
End Page
  • 1762
Grant/Funding Information
  • This work was supported in part by the Burroughs Wellcome Trust Career Award for Medical Scientists and the National Institutes of Health (NIH) Early Independence grant DP5OD019892 and U01 CA242109 to SS.
Abstract
  • Among responders to microbial invasion, neutrophils represent one of the earliest and perhaps most important factors that contribute to initial host defense. Effective neutrophil immunity requires their rapid mobilization to the site of infection, which requires efficient extravasation, activation, chemotaxis, phagocytosis, and eventual killing of potential microbial pathogens. Following pathogen elimination, neutrophils must be eliminated to prevent additional host injury and subsequent exacerbation of the inflammatory response. Galectins, expressed in nearly every tissue and regulated by unique sensitivity to oxidative and proteolytic inactivation, appear to influence nearly every aspect of neutrophil function. In this review, we will examine the impact of galectins on neutrophils, with a particular focus on the unique biochemical traits that allow galectin family members to spatially and temporally regulate neutrophil function.
Author Notes
Keywords
Research Categories
  • Engineering, Biomedical
  • Health Sciences, Immunology

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