Idiopathic remitting seronegative symmetrical synovitis with pitting edema syndrome with underlying history of malignancy.

• Type of Material: Article
• Authors: Kain Kim, Emory University; Charles Marvil, Emory University; Bhavin Adhyaru, Emory University
• Language: English
• Date: 2023-05
• Publisher: John Wiley & Sons Ltd
• Publication Version: Final Published Version
• Copyright Statement: © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1002/ccr3.7330
• Title of Journal or Parent Work: Clin Case Rep
• Volume: 11
• Issue: 5
• Start Page: e7330
• End Page: e7330
• Grant/Funding Information: The authors received no financial support for the research, authorship, and/or publication of this article.
• Keywords: synovitis; RS3PE; seronegative arthritis; polymyalgia rheumatica; edema; arthritis
• Research Categories: Health Sciences, Health Care Management; Health Sciences, Oncology

Abstract

KEY CLINICAL MESSAGE: By reporting this case, we hope to emphasize the importance of maintaining a high index of clinical suspicion for the early recognition of RS3PE in patients presenting with atypical symptoms of PMR and underlying history of malignancy. ABSTRACT: Remitting seronegative symmetrical synovitis with pitting edema is a rare rheumatic syndrome of unknown etiology. It shares qualities with many other common rheumatological disorders such as rheumatoid arthritis and polymyalgia rheumatica, making diagnosis especially challenging. RS3PE has been speculated to be a paraneoplastic syndrome, and those cases associated with underlying malignancy have shown to respond poorly to conventional treatment. Therefore, it is advisable to routinely screen patients with malignancy and presenting with RS3PE for cancer recurrence, even if in remission.