Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins

• Type of Material: Article
• Authors: Richard Kahn, Emory University; Jacqueline Cherfils, Centre National de la Recherche Scientifique Unitè de Recherche Associée; Marek Elias, Charles University Prague; Ruth C. Lovering, University College London; Sean Munro, Cambridge; Annette Schurmann, German Institute of Human Nutrition Potsdam-Rehbrücke
• Language: English
• Date: 2006-02-27
• Publisher: Rockefeller University Press
• Publication Version: Final Published Version
• Copyright Statement: © 2006, The Rockefeller University Press
• License: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1083/jcb.200512057
• Title of Journal or Parent Work: Journal of Cell Biology
• ISSN: 0021-9525
• Volume: 172
• Issue: 5
• Start Page: 645
• End Page: 650
• Grant/Funding Information: This work was supported by grants from the National Institutes of Health (GM68029 and GM67226 to R.A. Kahn), the Association pour la Recerche contre la Cancer (to J. Cherfils), and the French Research Ministry (ACI-BCMS to J. Cherfils).
• Keywords: Life Sciences & Biomedicine; Cell Biology; CHOLERA-TOXIN; Science & Technology; ENDOPLASMIC-RETICULUM; FACTOR DOMAIN; COPII VESICLE; CLONING; ADENYLATE-CYCLASE; GENOMIC ANALYSIS; NUCLEOTIDE; REGULATORY COMPONENT; ADP-RIBOSYLATION FACTOR
• Research Categories: Biology, Cell

Abstract

The Ras superfamily is comprised of at least four large families of regulatory guanosine triphosphate-binding proteins, including the Arfs. The Arf family includes three different groups of proteins: the Arfs, Arf-like (Arls), and SARs. Several Arf family members have been very highly conserved throughout eukaryotic evolution and have orthologues in evolutionally diverse species. The different means by which Arf family members have been identified have resulted in an inconsistent and confusing array of names. This confusion is further compounded by differences in nomenclature between different species. We propose a more consistent nomenclature for the human members of the Arf family that may also serve as a guide for nomenclature in other species. © The Rockefeller University Press.