Publication

Muscle Atrophy in Chronic Kidney Disease Results from Abnormalities in Insulin Signaling

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Last modified
  • 02/20/2025
Type of Material
Authors
    Russ Price, Emory UniversityJennifer Gooch, Emory UniversitySue K. Donaldson, Emory UniversityTiffany K. Roberts-Wilson, Emory University
Language
  • English
Date
  • 2010-09
Publisher
  • Elsevier: 12 months
Publication Version
Copyright Statement
  • © 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
License
Title of Journal or Parent Work
ISSN
  • 1051-2276
Volume
  • 20
Issue
  • 5 Suppl
Start Page
  • S24
End Page
  • S28
Grant/Funding Information
  • National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK
Abstract
  • Muscle atrophy is a significant consequence of chronic kidney disease (CKD) that increases a patient’s risk of mortality and decreases their quality of life. The loss of lean body mass results, in part, from an increase in the rate of muscle protein degradation. In this review, the proteolytic systems that are activated during CKD and the key insulin signaling pathways that regulate the protein degradative processes are described.
Author Notes
  • Corresponding author: Russ Price, Ph.D., Renal Division, Rm 338 Woodruff Memorial Research Building, 1639 Pierce Drive, Emory University, Atlanta, GA 30322, USA, russ.price@emory.edu, 404-727-3934 (office), 404-727-3425 (fax)
Research Categories
  • Health Sciences, Nutrition
  • Health Sciences, General

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