Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study

• Type of Material: Article
• Authors: Carlos Kase, Emory University; Hugo J. Aparicio, Boston University; Jayandra J. Himali, Boston University; Claudia L. Satizabal, Boston University; Matthew P. Pase, Florey Institute for Neuroscience and Mental Health, Melbourne, Australia; Jose R. Romero, Boston University; Alexa S. Beiser, Boston University; Sudha Seshadri, Boston University
• Language: English
• Date: 2019-06-01
• Publisher: Lippincott Williams & Wilkins
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2019 American Heart Association, Inc.
• Final Published Version (URL): http://dx.doi.org/10.1161/STROKEAHA.119.025171
• Title of Journal or Parent Work: Stroke
• Volume: 50
• Issue: 6
• Start Page: 1558
• End Page: 1560
• Grant/Funding Information: Supported by the National Heart, Lung, and Blood Institute N01-HC25195 and HHSN268201500001I, National Institute of Neurological Disorders and Stroke R01-NS017950, National Institute on Aging R01-AG054076–02S1 (HJA), Boston University’s Spivack Neurosciences Program and Aram V. Chobanian Assistant Professorship (HJA), and a National Heart Foundation of Australia Future Leader Fellowship 102052 (MPP).
• Keywords: Cardiovascular System & Cardiology; Peripheral Vascular Disease; cerebrovascular disorders; Life Sciences & Biomedicine; Mortality; epidemiology; risk factors; brain infarction; atrial fibrillation; Clinical Neurology; Science & Technology; Risk; Neurosciences & Neurology
• Research Categories: Health Sciences, Public Health; Biology, Neuroscience; Health Sciences, Epidemiology

Abstract

Background and Purpose: Stroke at midlife has a disproportionately large impact on disability-adjusted life-years lost. Ischemic stroke incidence may be increasing at this age. We investigated long-term trends in ischemic stroke incidence and changes in stroke risk factors in a community sample stratified by stroke onset at middle and older age. Methods: In the Framingham Study, surveillance for incident stroke is ongoing since 1948. We examined age-adjusted and sex-adjusted 10-year incidence of ischemic stroke using Cox models in persons aged 35 to 54 and ≥55 years at start of follow-up. Tests for linear trend were performed over 4 epochs, controlling for the distance in time between intervals. Further, we calculated the mean 10-year risk of stroke at each epoch and for both age groups, based on vascular risk factors from the Framingham Stroke Risk Profile. Results: There were 153, 197, 176, and 165 incident ischemic strokes within each epoch beginning in 1962 (n=3966), 1971 (n=5779), 1987 (n=5133), and 1998 (n=6964). Most ischemic strokes at midlife (n=71) were because of atherosclerotic brain infarction (n=50) or cardioembolism (n=19). Using the risk in the 1962 epoch as the reference, the risk of ischemic stroke at midlife did not significantly decline (hazard ratio, 0.87; 95% CI, 0.74-1.02; P trend =0.09). Incidence of ischemic stroke declined in the older group (hazard ratio, 0.82; 95% CI, 0.77-0.88; P trend <0.001). Between epochs 1 and 4, the average 10-year risk of stroke, as estimated by the Framingham Stroke Risk Profile, declined by 0.7% at midlife and 1.1% at older age. Conclusions: Long-term rates of ischemic stroke declined in our community sample; the decline was greater in older as compared with younger adults. Early prevention, focused on modification of cardiovascular risk factors, is important to see sustained declines in stroke incidence and mortality at midlife.