Meningioma: A Review of Epidemiology, Pathology, Diagnosis, Treatment, and Future Directions

• Type of Material: Article
• Authors: Christian Ogasawara, University of Hawaii School of Medicine; Brandon D Philbrick, Emory University; David Adamson, Emory University
• Language: English
• Date: 2021-03-01
• Publisher: MDPI
• Publication Version: Final Published Version
• Copyright Statement: © 2021 by the authors.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3390/biomedicines9030319
• Title of Journal or Parent Work: BIOMEDICINES
• Volume: 9
• Issue: 3
• Grant/Funding Information: This research received no external funding.
• Keywords: central nervous system; meningioma; CASE SERIES; benign; NERVOUS-SYSTEM; BRAIN-TUMORS; Pharmacology & Pharmacy; Biochemistry & Molecular Biology; malignant; CLASSIFICATION; Life Sciences & Biomedicine; Medicine, Research & Experimental; tumor; GENOMIC ANALYSIS; BAP1 MUTATIONS; GRADE; INTRACRANIAL MENINGIOMAS; RADIATION; Science & Technology; Research & Experimental Medicine; RISK
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Meningiomas are the most common intracranial tumor, making up more than a third of all primary central nervous system (CNS) tumors. They are mostly benign tumors that can be observed or preferentially treated with gross total resection that provides good outcomes. Meningiomas with complicated histology or in compromising locations has proved to be a challenge in treating and predicting prognostic outcomes. Advances in genomics and molecular characteristics of menin-giomas have uncovered potential use for more accurate grading and prediction of prognosis and recurrence. With the study and detection of genomic aberrancies, specific biologic targets are now being trialed for possible management of meningiomas that are not responsive to standard surgery and radiotherapy treatment. This review summarizes current epidemiology, etiology, molecular characteristics, diagnosis, treatments, and current treatment trials.