Management of chronic myeloid leukemia in children and adolescents: Recommendations from the Children's Oncology Group CML Working Group

• Type of Material: Article
• Authors: Uma Athale, Hamilton Health Sciences; Nobuko Hijiya, Northwestern University; Briana Patterson, Emory University; Daniel Bergsagel, Emory University; Jeffrey R. Andolina, University of Rochester; Henrique Bittencourt, Ste Justine University Hospital Center; Kirk R. Schultz, British Columbia Childrens Hospital; Michael J. Burke, Childrens Hospital of Wisconsin; Michele S. Redell, Baylor College of Medicine; E. Anders Kolb, Nemours/Alfred I DuPont Hospital for Children; Donna L. Johnston, Childrens Hospital of Eastern Ontario
• Language: English
• Date: 2019-09-01
• Publisher: Wiley
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2019 John Wiley & Sons, Inc. All rights reserved.
• Final Published Version (URL): http://dx.doi.org/10.1002/pbc.27827
• Title of Journal or Parent Work: Pediatric Blood & Cancer
• Volume: 66
• Issue: 9
• Start Page: e27827
• End Page: e27827
• Grant/Funding Information: This study was supported by NCTN Operations Center Grant U10CA180886.; This publication was supported by the Children’s Oncology Group.
• Keywords: Disease; Life Sciences & Biomedicine; Young adults; CML; Chronic myelogenous leukemia; Safety; Kinase inhibitors; Oncology; pediatric; recommendations; Imantinib cessation; Pediatrics; Cancer; Hematology; Science & Technology; Phase
• Research Categories: Health Sciences, Health Care Management; Health Sciences, Human Development; Health Sciences, Oncology

Abstract

Chronic myeloid leukemia (CML) accounts for 2-3% of leukemias in children under 15 and 9% in adolescents aged 15-19. The diagnosis and management of CML in children, adolescents, and young adults have several differences compared to that in adults. This review outlines the diagnosis and management of the underlying disease as well as challenges that can occur when dealing with CML in this patient population.