Clinicopathologic and Molecular Analysis of Inflammatory Pseudotumor-Like Follicular/Fibroblastic Dendritic Cell Sarcoma: A Case Report and Review of Literature

• Type of Material: Article
• Authors: bryan Morales-Vargas, Emory University; Kristin K. Deeb, Emory University; Deniz Peker Barclift, Emory University
• Language: English
• Date: 2021-09-15
• Publisher: Turkish Journal of Pathology
• Publication Version: Final Published Version
• Copyright Statement: © 2021 The Author(s).
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): https://doi.org/10.5146%2Ftjpath.2021.01523
• Title of Journal or Parent Work: Turkish Journal of Pathology
• Volume: 37
• Issue: 3
• Start Page: 266
• End Page: 272
• Keywords: JAK2; Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma; Splenic tumor; BCOR1L1
• Research Categories: Health Sciences, Oncology

Abstract

Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell (FDC/FRC) sarcoma is an extremely rare neoplasm of the spleen associated with EBV and characterized by spindle cell morphology, dense mixed chronic inflammatory background, and a broad immunophenotypic profile often causing a diagnostic challenge for pathologists. The molecular features of FDC/FRC sarcoma are largely unknown due to a lack of comprehensive data. Here we present the results of next-generation sequencing and Single Nucleotide Polymorphism Copy Number array analysis in a case of FDC/FRC and review the literature.