Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids

• Type of Material: Article
• Authors: Peijian He, Emory University; Sei-Jung Lee, Emory University; Songbai Lin, Emory University; Ursula Seidler, Hannover Medical School; Florian Lang, Tubingen University; Geza Fejes-Toth, Dartmouth Medical School; Aniko Naray-Fejes-Toth, Dartmouth Medical School; Chris Yun, Emory University
• Language: English
• Date: 2011-10-15
• Publisher: American Society for Cell Biology
• Publication Version: Final Published Version
• Copyright Statement: © 2011 He et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).
• License: Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
• Final Published Version (URL): http://www.molbiolcell.org/content/22/20/3812
• Title of Journal or Parent Work: Molecular Biology of the Cell
• ISSN: 1059-1524
• Volume: 22
• Issue: 20
• Start Page: 3812
• End Page: 3825
• Grant/Funding Information: P.H. and S.L. were supported by postdoctoral fellowships from the American Heart Association and Crohn's and Colitis Foundation of America, respectively.; This work was supported by grants from the National Institutes of Health (DK-061418 and DK-061418S1).
• Research Categories: Biology, Cell

Abstract

SGK1 plays an important role in regulation of Na+/H+ exchanger (NHE) 3 in vivo. We show that SGK3 colocalizes with NHE3 in recycling endosomes. These studies identify SGK3 as the effector of the PI3K pathway that activates NHE3 and show that endosomal localization of SGK3 is essential for acute activation of NHE3.