Publication
Immunohistochemical Distribution of PlexinA4 in the Adult Rat Central Nervous System
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- Persistent URL
- Last modified
- 02/20/2025
- Type of Material
- Authors
-
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Claire-Anne Gutekunst, Emory UniversityEric A. Stewart, Emory UniversityRobert E. Gross, Emory University
- Language
- English
- Date
- 2010-07-13
- Publisher
- Frontiers
- Publication Version
- Copyright Statement
- © 2010 Gutekunst, Stewart and Gross. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. - See more at: http://journal.frontiersin.org/Journal/10.3389/fnana.2010.00025/full#sthash.FhvEaV8n.dpuf
- Final Published Version (URL)
- Title of Journal or Parent Work
- ISSN
- 1662-5129
- Volume
- 4
- Issue
- 25
- Start Page
- 1
- End Page
- 17
- Grant/Funding Information
- This work was supported by a grant from NIH (K08 NS46322-01A1) to Robert E. Gross. Claire-Anne Gutekunst is funded in part by NIH (R03 NS58376-01A1).
- Abstract
- PlexinA4 is the latest member to be identified of the PlexinA subfamily, critical transducers of class 3 semaphorin signaling as co-receptors to neuropilins 1 and 2. Despite functional information regarding the role of PlexinA4 in development and guidance of specific neuronal pathways, little is known about its distribution in the adult central nervous system (CNS). Here we report an in depth immunohistochemical analysis of PlexinA4 expression in the adult rat CNS. PlexinA4 staining was present in neurons and fibers throughout the brain and spinal cord, including neocortex, hippocampus, lateral hypothalamus, red nucleus, facial nucleus, and the mesencephalic trigeminal nucleus. PlexinA4 antibodies labeled fibers in the lateral septum, nucleus accumbens, several thalamic nuclei, substantia nigra pars reticulata, zona incerta, pontine reticular region, as well as in several cranial nerve nuclei. This constitutes the first detailed description of the topographic distribution of PlexinA4 in the adult CNS and will set the basis for future studies on the functional implications of PlexinA4 in adult brain physiology.
- Author Notes
- Keywords
- Research Categories
- Biology, Neuroscience
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