Predictive and prognostic value of intravoxel incoherent motion (IVIM) MR imaging in patients with advanced cervical cancers undergoing concurrent chemo-radiotherapy.

• Type of Material: Article
• Authors: Li Zhu, The Affiliated Hospital of Nanjing University Medical School; Huanhuan Wang, The Affiliated Hospital of Nanjing University Medical School; Lijing Zhu, The Affiliated Hospital of Nanjing University Medical School; Jie Meng, The Affiliated Hospital of Nanjing University Medical School; Yan Xu, The Affiliated Hospital of Nanjing University Medical School; Baorui Liu, The Affiliated Hospital of Nanjing University Medical School; Weibo Chen, Philips Healthcare; Jian He, The Affiliated Hospital of Nanjing University Medical School; Zhengyang Zhou, The Affiliated Hospital of Nanjing University Medical School; Xiaofeng Yang, Emory University
• Language: English
• Date: 2017-09-14
• Publisher: Nature Publishing Group
• Publication Version: Final Published Version
• Copyright Statement: © The Author(s) 2017
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1038/s41598-017-11988-2
• Title of Journal or Parent Work: Scientific Reports
• ISSN: 2045-2322
• Volume: 7
• Issue: 1
• Start Page: 11635
• End Page: 11635
• Research Categories: Health Sciences, Radiology; Health Sciences, Oncology

Abstract

By using the intravoxel incoherent motion (IVIM) model, the diffusion-related coefficient (D) and the perfusion-related parameter (f) can be obtained simultaneously. Here, we explored the application of IVIM MR imaging in predicting long-term prognosis in patients with advanced cervical cancers treated with concurrent chemo-radiotherapy (CCRT). In this study, pelvic MR examinations including an IVIM sequence were performed on 30 women with advanced cervical cancers at three time points (within 2 weeks before, as well as 2 and 4 weeks after, the initiation of CCRT). The performance of tumour size and IVIM-derived parameters in predicting long-term prognosis was evaluated. After a median follow-up of 24 months (range, 10∼34 months), 25/30 (83.33%) patients were alive, and 21/30 (70.00%) remained free of disease. A shrinkage rate of maximum diameter (time point 1 vs. 3) ≥ 58.31% was useful in predicting a good long-term prognosis. The IVIM-derived apparent diffusion coefficient (ADCIVIM) value at time point 2 and the ADCIVIM and f values at time point 3 also performed well in predicting a good prognosis, with AUC of 0.767, 0.857 and 0.820, respectively. IVIM MR imaging has great potential in predicting long-term prognosis in patients with advanced cervical cancers treated with CCRT.