Role of Prenatal Characteristics and Early Growth on Pubertal Attainment of British Girls

• Type of Material: Article
• Authors: Mildred Maisonet, Emory University; Krista Yorita Christensen, Emory University; Carol Rubin, Centers for Disease Control and Prevention; Adrianne Holmes, Centers for Disease Control and Prevention; William Flanders, Emory University; Jon Heron, University of Bristol; Ken K. Ong, Institute of Metabolic Science; Jean Golding, University of Bristol; Michael A. McGeehin, Centers for Disease Control and Prevention; Michele Marcus, Emory University
• Language: English
• Date: 2010-09
• Publisher: American Academy of Pediatrics
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2010 by the American Academy of Pediatrics.
• Final Published Version (URL): http://dx.doi.org/10.1542/peds.2009-2636
• Title of Journal or Parent Work: Pediatrics
• ISSN: 0031-4005
• Volume: 126
• Issue: 3
• Start Page: E591
• End Page: E600
• Grant/Funding Information: The UK Medical Research Council, the Wellcome Trust, and the University of Bristol provide core support for ALSPAC.; This research was specifically funded by the Centers for Disease Control and Prevention.
• Keywords: CHILDHOOD; Tanner stages; SECULAR TRENDS; PEDIATRICS; obesity; puberty; SELF-REPORT; Life Sciences & Biomedicine; MENARCHE; RISK-FACTORS; BODY-FAT; postnatal growth; WEIGHT-GAIN; AGE; Science & Technology; ALSPAC; US GIRLS; Pediatrics; OBESITY
• Research Categories: Health Sciences, Epidemiology; Health Sciences, Human Development; Health Sciences, Public Health

Abstract

OBJECTIVES: The objective of this study was to explore the influence of maternal prenatal characteristics and behaviors and of weight and BMI gain during early childhood on the timing of various puberty outcomes in girls who were enrolled in the Avon Longitudinal Study of Parents and Children. METHODS: Repeated self-assessments of pubertal development were obtained from ∼4000 girls between the ages of 8 and 14. Data on prenatal characteristics and weight at birth and 2, 9, and 20 months of age were obtained from questionnaires, birth records, and clinic visits. Infants' weights were converted to weight-for-age and BMI SD scores (SDSs; z scores), and change values were obtained for the 0- to 20-month and other intervals within that age range. We used parametric survival models to estimate associations with age of entry into Tanner stages of breast and pubic hair and menarche. RESULTS: Maternal initiation of menarche at age < 12, smoking during pregnancy, and primiparity were associated with earlier puberty. A 1-unit increase in the weight SDS change values for the 0- to 20-month age interval was associated with earlier ages of entry into pubertal outcomes (0.19-0.31 years). Increases in the BMI SDS change values were also associated with earlier entry into pubertal outcomes (0.07-0.11 years). CONCLUSIONS: Many of the maternal prenatal characteristics and weight and BMI gain during infancy seemed to have similar influences across different puberty outcomes. Either such early factors have comparable influences on each of the hormonal processes involved in puberty, or processes are linked and awakening of 1 aspect triggers the others.