Publication

Editorial: Molecular Vaccines Against Pathogens in the Post-genomic Era

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Last modified
  • 05/20/2025
Type of Material
Authors
    Angel Alejandro Onate, Universidad de Concepción, ChileYanmin Wan, Fudan UniversityAlberto Moreno, Emory University
Language
  • English
Date
  • 2020-01-22
Publisher
  • Frontiers Media S.A.
Publication Version
Copyright Statement
  • © 2020 Oñate, Wan and Moreno.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 9
Start Page
  • 443
End Page
  • 443
Grant/Funding Information
  • AO received funded from the Fondo Nacional de Desarrollo Científico y Tecnológico, FONDECYT grants 1180122. AM received funded from the National Institutes of Health, NIAID grants R21 AI094402-01A1 and R21AI135711-01. YW received founded by project 81671636 and 81971559 from NSFC.
Abstract
  • The development and implementation of vaccines are one of the greatest Public Health achievements in human history (Centers-for-Disease-Control-and-Prevention, 2011a,b). In the first decade of the twenty-first century, the Expanded Program on Immunizations averts more than 2.5 million deaths every year (WHO, 2009). Vaccines not only prevent deaths, disease, and disability but also provide community protection by reducing the spread of the disease within a population (Orenstein and Ahmed, 2017). In the US alone, it has been estimated that the prevention of clinical cases and deaths by vaccination for a single birth cohort represents a net savings of $68.8 billion in total societal costs (Zhou et al., 2014). Although there are vaccines internationally available against 26 infectious diseases, nearly half of all deaths from infectious diseases are caused by pathogens for which no vaccine is available (Piot et al., 2019), including emerging and re-emerging pathogens (Williamson and Westlake, 2019). Interestingly, the majority of these vaccines have been developed empirically with limited information available on the mechanisms involved in protection (Pulendran and Ahmed, 2011). The development of high-throughput technologies and the advances in bioinformatics allow the massive generation and integration of datasets from multiple components of a biological system to understand in-depth physiological or pathological events (Pezeshki et al., 2019). This holistic approach of systems biology, when applied to studies of vaccine-induced immune responses, is known as system vaccinology (Pulendran et al., 2010). This research field will provide tools not only for the rational vaccine design but also for the development of novel adjuvants and vaccine delivery systems (Raeven et al., 2019). In this Frontiers Research Topic, some concepts of modern vaccinology are explored.
Author Notes
Keywords
Research Categories
  • Health Sciences, Epidemiology
  • Physics, Molecular
  • Health Sciences, Immunology
  • Biology, Microbiology

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