Banff 2011 Meeting Report: New Concepts in Antibody-Mediated Rejection

• Type of Material: Article
• Authors: M. Mengel, University of Alberta; B. Sis, University of Alberta; M. Haas, Cedars Sinai Med Ctr; R. B. Colvin, Harvard University; P. F. Halloran, University of Alberta; L. C. Racusen, Johns Hopkins University; K. Solez, University of Alberta; Linda Cendales, Emory University; A. J. Demetris, University of Pittsburgh; C. B. Drachenberg, University of Maryland; C. F. Farver, Cleveland Clinic; E. R. Rodriguez, Cleveland Clinic; W. D. Wallace, University of California at Los Angeles; D. Glotz, Hospital Saint-Louis; Alton Farris III, Emory University
• Language: English
• Date: 2014-02-01
• Publisher: Wiley: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.
• Final Published Version (URL): http://dx.doi.org/10.1111/ajt.12590
• Title of Journal or Parent Work: American Journal of Transplantation
• ISSN: 1600-6135
• Volume: 14
• Issue: 2
• Start Page: 272
• End Page: 283
• Grant/Funding Information: The participants of the 11th Banff Conference gratefully acknowledge the financial support provided by the following companies and institutions: Astellas, Novartis, Roche, Pfizer, One Lambda, CSL Behring, Transpath, Alexion, Aperio, Philips, Omnyx, University of Alberta, National Kidney Foundation and Renal Pathology Society.
• Keywords: pancreas allograft; LUNG TRANSPLANTATION; RENAL-ALLOGRAFT BIOPSIES; KIDNEY-TRANSPLANT RECIPIENTS; Transplantation; Surgery; liver allograft; cardiac allograft; complement C4d; GLOMERULOPATHY; Science & Technology; transplant glomerulopathy; INFLAMMATION; Acute allograft rejection; antibody-mediated rejection; Life Sciences & Biomedicine; chronic allograft rejection; composite tissue allograft; transplant pathology; CLASSIFICATION; Banff schema; lung transplantation; DONOR-SPECIFIC ANTIBODIES; donor-specific antibodies; C4D; PATHOLOGY; PROTOCOL BIOPSIES; transplant biopsy; renal transplantation
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

The 12th Banff Conference on Allograft Pathology was held in Comandatuba, Brazil, from August 19-23, 2013, and was preceded by a 2-day Latin American Symposium on Transplant Immunobiology and Immunopathology. The meeting was highlighted by the presentation of the findings of several working groups formed at the 2009 and 2011 Banff meetings to: (1) establish consensus criteria for diagnosing antibody-mediated rejection (ABMR) in the presence and absence of detectable C4d deposition; (2) develop consensus definitions and thresholds for glomerulitis (g score) and chronic glomerulopathy (cg score), associated with improved inter-observer agreement and correlation with clinical, molecular and serological data; (3) determine whether isolated lesions of intimal arteritis ("isolated v") represent acute rejection similar to intimal arteritis in the presence of tubulointerstitial inflammation; (4) compare different methodologies for evaluating interstitial fibrosis and for performing/evaluating implantation biopsies of renal allografts with regard to reproducibility and prediction of subsequent graft function; and (5) define clinically and prognostically significant morphologic criteria for subclassifying polyoma virus nephropathy. The key outcome of the 2013 conference is defining criteria for diagnosis of C4d-negative ABMR and respective modification of the Banff classification. In addition, three new Banff Working Groups were initiated. The 2013 Banff Transplant Conference defines revised, consensus criteria for acute/active and chronic, active antibody-mediated rejection in renal allograft biopsies, criteria that include C4d-negative antibody-mediated rejection and antibody-associated arterial lesions.