Barriers, supports, and effective interventions for uptake of human papillomavirus- and other vaccines within global and Canadian Indigenous peoples: a systematic review protocol

• Type of Material: Article
• Authors: Kelly J. Mrklas, Alberta Health Services; Shannon MacDonald, University of Alberta; Melissa A. Shea-Budgell, University of Calgary; Nancy Bedingfield, University of Calgary; Heather Ganshorn, University of Calgary; Sarah Glaze, University of Calgary; Lea Bill, Alberta First Nations Information Governance Centre; Bonnie Healy, Alberta First Nations Information Governance Centre; Chyloe Healy, Alberta First Nations Information Governance Centre; Juliet Guichon, University of Calgary; Amy Colquhoun, Alberta Health; Christopher Bell, Alberta Health; Ruth Richardson, Health Canada; Rita Henderson, University of Calgary; James Kellner, University of Calgary; Cheryl Barnabe, University of Calgary; Robert A. Bednarczyk, Emory University; Angeline Letendre, Alberta Cancer Prevention Legacy Fund; Gregg S. Nelson, University of Calgary
• Language: English
• Date: 2018-03-02
• Publisher: Medknow Publications
• Publication Version: Final Published Version
• Copyright Statement: © 2018 The Author(s).
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1186/s13643-018-0692-y
• Title of Journal or Parent Work: Systematic Reviews in Pharmacy
• ISSN: 0975-8453
• Volume: 7
• Issue: 1
• Start Page: 40
• End Page: 40
• Grant/Funding Information: This work is funded by Alberta Innovates - Health Solutions through the Cancer Prevention Research Opportunity [2015 Collaborative Research and Innovation Opportunity (CRIO)] Grant #201500852.
• Keywords: Vaccination; Uptake; Cancer prevention; Supports; Barriers; Hesitancy; Acceptance; Indigenous populations; Human papillomavirus (HPV)
• Research Categories: Health Sciences, Public Health

Abstract

Despite the existence of human papilloma virus (HPV) vaccines with demonstrated safety and effectiveness and funded HPV vaccination programs, coverage rates are persistently lower and cervical cancer burden higher among Canadian Indigenous peoples. Barriers and supports to HPV vaccination in Indigenous peoples have not been systematically documented, nor have interventions to increase uptake in this population. This protocol aims to appraise the literature in Canadian and global Indigenous peoples, relating to documented barriers and supports to vaccination and interventions to increase acceptability/uptake or reduce hesitancy of vaccination. Although HPV vaccination is the primary focus, we anticipate only a small number of relevant studies to emerge from the search and will, therefore, employ a broad search strategy to capture literature related to both HPV vaccination and vaccination in general in global Indigenous peoples. Methods: Eligible studies will include global Indigenous peoples and discuss barriers or supports and/or interventions to improve uptake or to reduce hesitancy, for the HPV vaccine and/or other vaccines. Primary outcomes are documented barriers or supports or interventions. All study designs meeting inclusion criteria will be considered, without restricting by language, location, or data type. We will use an a priori search strategy, comprised of key words and controlled vocabulary terms, developed in consultation with an academic librarian, and reviewed by a second academic librarian using the PRESS checklist. We will search several electronic databases from date of inception, without restrictions. A pre-defined group of global Indigenous websites will be reviewed for relevant gray literature. Bibliographic searches will be conducted for all included studies to identify relevant reviews. Data analysis will include an inductive, qualitative, thematic synthesis and a quantitative analysis of measured barriers and supports, as well as a descriptive synthesis and quantitative summary of measures for interventions. Discussion: To our knowledge, this study will contribute the first systematic review of documented barriers, supports, and interventions for vaccination in general and for HPV vaccination. The results of this study are expected to inform future research, policies, programs, and community-driven initiatives to enhance acceptability and uptake of HPV vaccination among Indigenous peoples. Systematic review registration: PROSPERO Registration Number: CRD42017048844.