Publication

Aberrant resting-state functional connectivity in incarcerated women with elevated psychopathic traits.

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Last modified
  • 06/25/2025
Type of Material
Authors
    Corey H. Allen, The Mind Research NetworkJ. Michael Maurer, The Mind Research NetworkBethany G. Edwards, The Mind Research NetworkAparna R. Gullapalli, The Mind Research NetworkCarla L. Harenski, The Mind Research NetworkKeith A. Harenski, The Mind Research NetworkVince Calhoun, Emory UniversityKent A. Kiehl, The Mind Research Network
Language
  • English
Date
  • 2022
Publisher
  • Frontiers
Publication Version
Copyright Statement
  • © 2022 Allen, Maurer, Edwards, Gullapalli, Harenski, Harenski, Calhoun and Kiehl.
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 1
Start Page
  • 971201
End Page
  • 971201
Grant/Funding Information
  • This material is based upon work supported by the National Institute on Drug Abuse (NIDA; R01 DA020870 and R01 DA026964) and National Institute of Mental Health (NIMH; R01 MH085010).
Supplemental Material (URL)
Abstract
  • Previous work in incarcerated men suggests that individuals scoring high on psychopathy exhibit aberrant resting-state paralimbic functional network connectivity (FNC). However, it is unclear whether similar results extend to women scoring high on psychopathy. This study examined whether psychopathic traits [assessed via the Hare Psychopathy Checklist - Revised (PCL-R)] were associated with aberrant inter-network connectivity, intra-network connectivity (i.e., functional coherence within a network), and amplitude of fluctuations across limbic and surrounding paralimbic regions among incarcerated women (n = 297). Resting-state networks were identified by applying group Independent Component Analysis to resting-state fMRI scans. We tested the association of psychopathic traits (PCL-R Factor 1 measuring interpersonal/affective psychopathic traits and PCL-R Factor 2 assessing lifestyle/antisocial psychopathic traits) to the three FNC measures. PCL-R Factor 1 scores were associated with increased low-frequency fluctuations in executive control and attentional networks, decreased high-frequency fluctuations in executive control and visual networks, and decreased intra-network FNC in default mode network. PCL-R Factor 2 scores were associated with decreased high-frequency fluctuations and default mode networks, and both increased and decreased intra-network functional connectivity in visual networks. Similar to previous analyses in incarcerated men, our results suggest that psychopathic traits among incarcerated women are associated with aberrant intra-network amplitude fluctuations and connectivity across multiple networks including limbic and surrounding paralimbic regions.
Author Notes
Keywords
Research Categories
  • Health Sciences, Pathology
  • Biology, Neuroscience

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