New Connections: Cell-to-Cell HIV-1 Transmission, Resistance to Broadly Neutralizing Antibodies, and an Envelope Sorting Motif

• Type of Material: Article
• Authors: S. Abigail Smith, Emory University; Cynthia Derdeyn, Emory University
• Language: English
• Date: 2017-05-01
• Publisher: American Society for Microbiology
• Publication Version: Final Published Version
• Copyright Statement: © 2017 American Society for Microbiology. All rights reserved.
• Final Published Version (URL): http://dx.doi.org/10.1128/JVI.00149-17
• Title of Journal or Parent Work: Journal of Virology
• ISSN: 0022-538X
• Volume: 91
• Issue: 9
• Start Page: e00149-17
• End Page: e00149-1
• Keywords: Science & Technology; GP41 CYTOPLASMIC TAIL; ENDOCYTOSIS; TYROSINE; viral envelope; VIRION MATURATION; TYPE-1 INFECTION; Life Sciences & Biomedicine; VIROLOGICAL SYNAPSES; Virology; human immunodeficiency virus; HUMAN-IMMUNODEFICIENCY-VIRUS; broadly neutralizing antibody; TARGET-CELLS; virological synapse; MEMBRANE-FUSION; TRAFFICKING MOTIF
• Research Categories: Biology, Microbiology; Health Sciences, Immunology; Biology, Virology

Abstract

HIV-1 infection from cell-to-cell may provide an efficient mode of viral spread in vivo and could therefore present a significant challenge for preventative or therapeutic strategies based on broadly neutralizing antibodies. Indeed, Li et al. (H. Li, C. Zony, P. Chen, and B. K. Chen, J. Virol. 91:e02425-16, 2017, https://doi.org/ 10.1128/JVI.02425-16) showed that the potency and magnitude of multiple HIV-1 broadly neutralizing antibody classes are decreased during cell-to-cell infection in a context-dependent manner. A functional motif in gp41 appears to contribute to this differential susceptibility by modulating exposure of neutralization epitopes.