Development of next-generation respiratory virus vaccines through targeted modifications to viral immunomodulatory genes

• Type of Material: Article
• Authors: Christopher C. Stobart, Emory University; Martin Moore, Emory University
• Language: English
• Date: 2015-12-02
• Publisher: Expert Reviews (formerly Future Drugs)
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2015 Taylor & Francis.
• Final Published Version (URL): http://dx.doi.org/10.1586/14760584.2015.1095096
• Title of Journal or Parent Work: Expert Review of Vaccines
• ISSN: 1476-0584
• Volume: 14
• Issue: 12
• Start Page: 1563
• End Page: 1572
• Grant/Funding Information: This work was supported by NIH grants R01AI087798 (MLM), U19 AI095227 (MLM), and T32 AI074492 (CCS) and the Emory Children’s Center for Childhood Infections and Vaccines (CCIV).
• Keywords: Immunology; G-GLYCOPROTEIN; NS1 PROTEIN; mumps; Life Sciences & Biomedicine; MUMPS-VIRUS; coronavirus; PRE-MESSENGER-RNAS; SYNCYTIAL VIRUS; INFLUENZA-A VIRUS; pathogenesis; measles; SMALL HYDROPHOBIC PROTEIN; ATTENUATED IN-VITRO; Science & Technology; respiratory viruses; NF-KAPPA-B; next-generation vaccines; respiratory syncytial virus; influenza; SYNDROME CORONAVIRUS
• Research Categories: Health Sciences, Immunology; Biology, Virology

Abstract

Vaccines represent one of the greatest contributions of the scientific community to global health. Yet, many pathogens remain either unchallenged or inadequately hindered by commercially available vaccines. Respiratory viruses pose distinct and difficult challenges due to their ability to rapidly spread, adapt, and modify the host immune response. Considerable research has been directed to understand the role of respiratory virus immunomodulatory proteins and how they influence the host immune response. We review here efforts to develop next-generation vaccines through targeting these key immunomodulatory genes in influenza virus, coronaviruses, respiratory syncytial virus, measles virus, and mumps virus.