NIH Workshop 2018: Towards Minimally Invasive or Noninvasive Approaches to Assess Tissue Oxygenation Pre- and Post-transfusion

• Type of Material: Article
• Authors: Margaret J Ochocinska, National Heart, Lung, and Blood Institute, Bethesda; Steven L Spitalnik, Columbia University; Alfred Abuhamad, Eastern Virginia Medical School; Elliott Bennett-Guerrero, Stony Brook University; Waldemar A Carlo, UAB School of Medicine; Murali Cherukuri, National Cancer Institute, Bethesda; Allan Doctor, University of Maryland; Walter Dzik, Harvard University; Conor L Evans, Harvard Medical School; Erica Forzani, Arizona State University-Tempe; Periannan Kuppusamy, Geisel College of Medicine at Dartmouth; Natacha Le Moan, Catalyst Biosciences; Lei Li, California Institute of Technology; Naomi Luban, Children’s National Medical Center; Narla Mohandas, New York Blood Center; Ravi Patel, Emory University; John Roback, Emory University; Harold Swartz, Geisel College of Medicine at Dartmouth; Stephen Textor, Mayo Clinic, Rochester; Sergei Vinogradov, University of Pennsylvania; Lihong Wang, California Institute of Technology; Natalie Wisniewski, Profusa Inc; Simone Glynn, National Heart, Lung, and Blood Institute
• Language: English
• Date: 2021-03-10
• Publisher: W B SAUNDERS CO-ELSEVIER INC
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2020 Elsevier Inc. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.tmrv.2020.12.003
• Title of Journal or Parent Work: TRANSFUSION MEDICINE REVIEWS
• Volume: 35
• Issue: 1
• Start Page: 46
• End Page: 55
• Keywords: STORAGE; Perfusion; Blood transfusion; Science & Technology; TRANSFUSION; Life Sciences & Biomedicine; Hematology; RED-BLOOD-CELLS; Oxygenation

Abstract

Because blood transfusion is one of the most common therapeutic interventions in hospitalized patients, much recent research has focused on improving the storage quality in vitro of donor red blood cells (RBCs) that are then used for transfusion. However, there is a significant need for enhancing our understanding of the efficacy of the transfused RBCs in vivo. To this end, the NIH sponsored a one-and-a-half-day workshop that brought together experts in multiple disciplines relevant to tissue oxygenation (eg, transfusion medicine, critical care medicine, cardiology, neurology, neonatology and pediatrics, bioengineering, biochemistry, and imaging). These individuals presented their latest findings, discussed key challenges, and aimed to identify opportunities for facilitating development of new technologies and/or biomarker panels to assess tissue oxygenation in a minimally-invasive to noninvasive fashion, before and after RBC transfusion.