Tuberculosis interferon-gamma responses in the breast milk of human immunodeficiency virus infected mothers

• Type of Material: Article
• Authors: Lisa Cranmer, Emory University; Mercy Kanyugo, University of Nairobi; Barbara Lohman-Payne, University of Nairobi; Ken Tapia, University of Washington; Grace C. John-Stewart, University of Washington
• Language: English
• Date: 2015-02-01
• Publisher: International Union Against Tuberculosis and Lung Disease
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2015 The Union.
• Final Published Version (URL): http://dx.doi.org/10.5588/ijtld.14.0384
• Title of Journal or Parent Work: International Journal of Tuberculosis and Lung Disease
• ISSN: 1027-3719
• Volume: 19
• Issue: 2
• Start Page: 141
• End Page: 143
• Grant/Funding Information: GJ-S is supported by NIH K24 HD054314-04.; BL-P was a scholar in the International AIDS Training and Research Program, NIH Research Grant D43 TW000007, funded by the Fogarty International Center and the Office of Research on Women's Health.; Supported by the US National Institutes Health NIH HD058477-01.; LC was a Fellow of the Pediatric Scientist Development Program (PSDP) supported by an American Pediatric Society/American Academy of Pediatrics grant and NICHD K12-HD000850.; This publication was made possible with help from the University of Washington Center for AIDS Research (CFAR), an NIH funded program (P30 AI027757), which is supported by the following NIH Institutes and Centers (NIAID, NCI, NIMH, NIDA, NICHD, NHLBI, NIA).
• Keywords: TB; maternal; Respiratory System; Life Sciences & Biomedicine; IGRA; Science & Technology; HIV; Infectious Diseases; infant; TRANSMISSION
• Research Categories: Health Sciences, Public Health; Health Sciences, Epidemiology; Biology, Cell

Abstract

Tuberculosis (TB) cellular immune responses were examined in the breast milk of human immunodeficiency virus infected mothers using the T-SPOT®.TB interferon-gamma release assay (IGRA). Positive TB interferon-gamma (IFN-γ) responses were detected in 6 of 8 (75%) valid breast milk assays. Among 7 mothers with paired breast milk and blood assays, TB IFN-γ responses were higher in breast milk than in blood (P = 0.02). The magnitude of TB IFN-γ responses in maternal breast milk and blood were correlated. Elucidating the influence of TB immune responses in breast milk on infant TB susceptibility and immunity may inform future maternal TB vaccine strategies.