Publication

Cancer vaccine development: Designing tumor cells for greater immunogenicity

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Last modified
  • 05/20/2025
Type of Material
Authors
    Erica N. Bozeman, Emory UniversityRangaiah Shashidharamurthy, Emory UniversitySimon A. Paulos, Mercer UniversityRavi Palaniappan, Mercer UniversityMartin D'Souza, Mercer UniversityPeriasamy Selvaraj, Emory University
Language
  • English
Date
  • 2010-01-01
Publisher
  • Frontiers in Bioscience
Publication Version
Copyright Statement
  • © 2015 Frontiers in Bioscience. All rights reserved.
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1093-9946
Volume
  • 15
Issue
  • 1
Start Page
  • 309
End Page
  • 320
Grant/Funding Information
  • Grant support: NIH R01 CA138993.
Abstract
  • Cancer vaccine development is one of the most hopeful and exhilarating areas in cancer research. For this reason, there has been a growing interest in the development and application of novel immunotherapies for the treatment of cancer with the focus being on stimulating the immune system to target tumor cells specifically while leaving normal cells unharmed. From such research has emerged a host of promising immunotherapies such as dendritic cell-based vaccines, cytokine therapies and gene transfer technology. These therapies seek to counteract the poor immunogenicity of tumors by augmenting the host's immune system with a variety of immunostimulatory proteins such as cytokines and costimulatory molecules. While such therapies have proven effective in the induction of anti-tumor immunity in animal models, they are less than optimal and pose a high risk of clinical infeasibility. Herein, we further discuss these immunotherapies as well as a feasible and efficient alternative that, in pre-clinical animal models, allows for the expression of specific immunostimulatory molecules on the surface of tumor cells by a novel protein transfer technology.
Author Notes
  • Send correspondence to: Periasamy Selvaraj, Ph.D., Department of Pathology, Emory University School of Medicine, 7309 Woodruff Memorial Building 101 Woodruff Circle Atlanta, GA 30322, Tel: 404-727-5929, Fax: 404-727-5764, E-mail:pselvar@emory.edu
Keywords
Research Categories
  • Health Sciences, Oncology
  • Health Sciences, Immunology

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