Maternal weight affects placental DNA methylation of genes involved in metabolic pathways in the common marmoset monkey (Callithrix jacchus)

• Type of Material: Article
• Authors: Laren Narapareddy, Emory University; Derek E Wildman, University of South Florida; Don L Armstrong, University of Illinois at Urbana‐Champaign; Amy Weckle, University of Illinois at Urbana‐Champaign; Aleeca F Bell, University of Illinois at Urbana‐Champaign; Crystal L Patil, University of Illinois at Urbana‐Champaign; Suzette D Tardif, Southwest National Primate Research Center; Corinna N Ross, Texas A&M University‐San Antonio; Julienne N Rutherford, University of Illinois at Urbana‐Champaign
• Language: English
• Date: 2020-02-05
• Publisher: WILEY
• Publication Version: Final Published Version
• Copyright Statement: © 2020 The Authors. American Journal of Primatology published by Wiley Periodicals, Inc.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1002/ajp.23101
• Title of Journal or Parent Work: AMERICAN JOURNAL OF PRIMATOLOGY
• Volume: 82
• Issue: 3
• Start Page: e23101
• End Page: e23101
• Keywords: EPIGENETICS; obesity; GROWTH; MODEL; maternal metabolism; developmental programming; CORD BLOOD; non-human primate; Zoology; NONHUMAN PRIMATE; Life Sciences & Biomedicine; epigenetics; Science & Technology; CHIMERISM
• Research Categories: Health Sciences, Nursing; Health Sciences, Public Health

Abstract

Accumulating evidence suggests that dysregulation of placental DNA methylation (DNAm) is a mechanism linking maternal weight during pregnancy to metabolic programming outcomes. The common marmoset, Callithrix jaccus, is a platyrrhine primate species that has provided much insight into studies of the primate placenta, maternal condition, and metabolic programming, yet the relationships between maternal weight and placental DNAm are unknown. Here, we report genome-wide DNAm from term marmoset placentas using reduced representation bisulfite sequencing. We identified 74 genes whose DNAm pattern is associated with maternal weight during gestation. These genes are predominantly involved in energy metabolism and homeostasis, including the regulation of glycolytic and lipid metabolic processes pathways.