Differentiating among stages of cognitive impairment in aging: Version 3 of the Uniform Data Set (UDS) neuropsychological test battery and MoCA index scores.

• Type of Material: Article
• Authors: Hiroko H. Dodge, Layton Aging and Alzheimer's Disease Center Oregon Health & Science University; Felicia Goldstein, Emory University; Nicole I. Wakim, Department of Biostatistics University of Michigan; Tamar Gefen, The Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University; Merilee Teylan, National Alzheimer's Coordinating Center University of Washington; Kwun C.G. Chan, National Alzheimer's Coordinating Center University of Washington; Walter A. Kukull, National Alzheimer's Coordinating Center University of Washington; Lisa L. Barnes, Rush Alzheimer's Disease Center Rush University Medical Center; Bruno Giordani, Michigan Alzheimer's Disease Center University of Michigan; Timothy M. Hughes, The Wake Forest Alzheimer's Disease Research Center, Wake Forest School of Medicine; Joel H. Kramer, Memory and Aging Center University of California San Francisco; David A. Loewenstein, Center for Cognitive Neuroscience and Aging University of Miami Miller School of Medicine; Daniel C. Marson, Alzheimer's Disease Center University of Alabama at Birmingham; Dan M. Mungas, The UC Davis Alzheimer's Disease Research Center; Nora Mattek, Layton Aging and Alzheimer's Disease Center Oregon Health & Science University; Bonnie C. Sachs, The Wake Forest Alzheimer's Disease Research Center, Wake Forest School of Medicine; David P. Salmon, The Shiley-Marcos Alzheimer's Disease Research Center University of California, San Diego; Monica Parker, Emory University; Kathleen A. Welsh-Bohmer, Alzheimer's Disease Research Center Duke University; Katherine V. Wild, Layton Aging and Alzheimer's Disease Center Oregon Health & Science University; John C. Morris, Knight Alzheimer Disease Research Center Washington University School of Medicine; Sandra Weintraub, The Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University
• Language: English
• Date: 2020
• Publisher: Wiley Periodicals, Inc.
• Publication Version: Final Published Version
• Copyright Statement: © 2020 The Authors.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1002/trc2.12103
• Title of Journal or Parent Work: Alzheimers Dement (N Y)
• Volume: 6
• Issue: 1
• Start Page: e12103
• End Page: e12103
• Grant/Funding Information: The NACC database is funded by NIA/NIH Grant U01 AG016976. NACC data are contributed by the NIA‐funded ADCs: P30 AG019610 (PI Eric Reiman, MD), P30 AG013846 (PI Neil Kowall, MD), P50 AG008702 (PI Scott Small, MD), P50 AG025688 (PI Allan Levey, MD, PhD), P50 AG047266 (PI Todd Golde, MD, PhD), P30 AG010133 (PI Andrew Saykin, PsyD), P50 AG005146 (PI Marilyn Albert, PhD), P50 AG005134 (PI Bradley Hyman, MD, PhD), P50 AG016574 (PI Ronald Petersen, MD, PhD), P50 AG005138 (PI Mary Sano, PhD), P30 AG008051 (PI Thomas Wisniewski, MD), P30 AG013854 (PI M. Marsel Mesulam, MD), P30 AG008017 (PI Jeffrey Kaye, MD), P30 AG010161 (PI David Bennett, MD), P50 AG047366 (PI Victor Henderson, MD, MS), P30 AG010129 (PI Charles DeCarli, MD), P50 AG016573 (PI Frank LaFerla, PhD), P50 AG005131 (PI James Brewer, MD, PhD), P50 AG023501 (PI Bruce Miller, MD), P30 AG035982 (PI Russell Swerdlow, MD), P30 AG028383 (PI Linda Van Eldik, PhD), P30 AG053760 (PI Henry Paulson, MD, PhD), P30 AG010124 (PI John Trojanowski, MD, PhD), P50 AG005133 (PI Oscar Lopez, MD), P50 AG005142 (PI Helena Chui, MD), P30 AG012300 (PI Roger Rosenberg, MD), P30 AG049638 (PI Suzanne Craft, PhD), P50 AG005136 (PI Thomas Grabowski, MD), P50 AG033514 (PI Sanjay Asthana, MD, FRCP), P50 AG005681 (PI John Morris, MD), P50 AG047270 (PI Stephen Strittmatter, MD, PhD), and P30 AG053760 (PI Henry Paulson, MD).
• Keywords: receiver‐operating characteristic area under the curve (ROC‐AUC); validity; differentiating CDR; racial differences; optimal cut‐point; National Alzheimer's Coordinating Center Uniform Data Set (NACC UDS)
• Research Categories: Health Sciences, Public Health; Biology, Neuroscience

Abstract

INTRODUCTION: Federally funded Alzheimer's Disease Centers in the United States have been using a standardized neuropsychological test battery as part of the National Alzheimer's Coordinating Center Uniform Data Set (UDS) since 2005. Version 3 (V3) of the UDS replaced the previous version (V2) in 2015. We compared V2 and V3 neuropsychological tests with respect to their ability to distinguish among the Clinical Dementia Rating (CDR) global scores of 0, 0.5, and 1. METHODS: First, we matched participants receiving V2 tests (V2 cohort) and V3 tests (V3 cohort) in their cognitive functions using tests common to both versions. Then, we compared receiver-operating characteristic (ROC) area under the curve in differentiating CDRs for the remaining tests. RESULTS: Some V3 tests performed better than V2 tests in differentiating between CDR 0.5 and 0, but the improvement was limited to Caucasian participants. DISCUSSION: Further efforts to improve the ability for early identification of cognitive decline among diverse racial groups are required.