Could Nutraceutical Approaches Possibly Attenuate the Cytokine Storm in COVID-19 Patients?

• Type of Material: Article
• Authors: Ramachandran Vignesh, University of Kuala Lumpur; Vijayakumar Velu, Emory University; Sripathi M Sureban, The University of Oklahoma
• Language: English
• Date: 2021-04-23
• Publisher: FRONTIERS MEDIA SA
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2021 Vignesh, Velu and Sureban
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3389/fcimb.2021.667733
• Title of Journal or Parent Work: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
• Volume: 11
• Start Page: 667733
• End Page: 667733
• Grant/Funding Information: VV was supported by National Institutes of Health Grants 1R01AI148377-01A1, R01 HD095741-01, CFAR R03 (to VV), Emory University CFAR grant P30 AI050409 and NCRR/NIH base grants P30 RR00165, P51OD011132 (to Y.N.P.R.C).
• Keywords: IMPACT; MECHANISMS; ACE2; SARS-CoV-2; probiotics; Pectin; PROBIOTICS; SARS-COV-2; FLAVONOIDS; FATTY-ACIDS; Life Sciences & Biomedicine; nutraceuticals; gut microbiota; Science & Technology; COVID-19; OMEGA-3-FATTY-ACIDS; Microbiology; Immunology; INFLAMMATION
• Research Categories: Health Sciences, Medicine and Surgery; Health Sciences, Pathology

Abstract

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a colossal impact on public health, testified by being announced as a global pandemic by the World Health Organization (WHO) in March 2020. As of 1st April 2021, there have been over 128,223,872 confirmed cases of COVID-19 and over 2,804,120 fatalities reported by WHO (WHO Coronavirus Disease (COVID-19) Dashboard, 2021). Though COVID-19 vaccines are developed and being deployed around the world, considering the logistic challenges, vaccine-induced herd immunity is still a long way off (Vignesh et al., 2020). Despite being primarily a respiratory disease, mounting pieces of evidence point towards the impact of COVID-19 on the gastrointestinal system and the presentation of gastrointestinal (GI) manifestations (McDermott et al., 2020). In this opinion article, we summarize the effects of COVID-19 on the GI tract and also provide evidence of the role of nutraceuticals as a potential treatment strategy against COVID-19.