Publication

Risk Factors for Seizures Among Young Children Monitored With Continuous Electroencephalography in Intensive Care Unit: A Retrospective Study

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Last modified
  • 05/21/2025
Type of Material
Authors
    Jan Vlachy, Georgia Institute of TechnologyMingyoung Jo, Childrens Healthcare AtlantaQing Li, Johns Hopkins Applied Physics LabTurgay Ayer, Georgia Institute of TechnologyPinar Keskinocak, Georgia Institute of TechnologyJulie Swann, North Carolina State UniversityLarry Olson, Emory UniversityAtul Vats, Emory University
Language
  • English
Date
  • 2018-10-15
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2018 Vlachy, Jo, Li, Ayer, Keskinocak, Swann, Olson and Vats.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 2296-2360
Volume
  • 6
Start Page
  • 303
End Page
  • 303
Supplemental Material (URL)
Abstract
  • Objective: cEEG is an emerging technology for which there are no clear guidelines for patient selection or length of monitoring. The purpose of this study was to identify subgroups of pediatric patients with high incidence of seizures. Study Design: We conducted a retrospective study on 517 children monitored by cEEG in the intensive care unit (ICU) of a children's hospital. The children were stratified using an age threshold selection method. Using regression modeling, we analyzed significant risk factors for increased seizure risk in younger and older children. Using two alternative correction procedures, we also considered a relevant comparison group to mitigate selection bias and to provide a perspective for our findings. Results: We discovered an approximate risk threshold of 14 months: below this threshold, the seizure risk increases dramatically. The older children had an overall seizure rate of 18%, and previous seizures were the only significant risk factor. In contrast, the younger children had an overall seizure rate of 45%, and the seizures were significantly associated with hypoxic-ischemic encephalopathy (HIE; p = 0.007), intracranial hemorrhage (ICH; p = 0.005), and central nervous system (CNS) infection (p = 0.02). Children with HIE, ICH, or CNS infection accounted for 61% of all seizure patients diagnosed through cEEG under 14 months. Conclusions: An extremely high incidence of seizures prevails among critically ill children under 14 months, particularly those with HIE, ICH, or CNS infection.
Author Notes
Keywords
Research Categories
  • Health Sciences, General
  • Biology, Neuroscience

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