A review of key strategies to address the shortage of analgesics and sedatives in pediatric intensive care

• Type of Material: Article
• Authors: Roberto Esteves Vierira de Castro, Rio de Janeiro State University; Miguel Rodriguez-Rubio, Hospital Universitario La Paz; Maria Clara de Magalhães-Barbosa, D'Or Institute for Research and Education; Arnaldo Prata-Barbosa, D'Or Institute for Research and Education; Jaimee Holbrook, University of Chicago Medicine; Pradip Kamat, Emory University; Anne Stormorken, Case Western Reserve University
• Language: English
• Date: 2022-08-30
• Publisher: FRONTIERS MEDIA SA
• Publication Version: Final Published Version
• Copyright Statement: © 2022 Castro, Rodríguez-Rubio, Magalhães-Barbosa, Prata-Barbosa, Holbrook, Kamat and Stormorken.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3389/fped.2022.895541
• Title of Journal or Parent Work: FRONTIERS IN PEDIATRICS
• Volume: 10
• Start Page: 895541
• End Page: 895541
• Keywords: pediatrics; Pediatrics; PAIN; Science & Technology; analgesia; DRUG SHORTAGES; DELIRIUM; sedation; delirium; MANAGEMENT; Life Sciences & Biomedicine; COVID-19; PREVENTION; ANTIPSYCHOTICS; CHILDREN
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Importance: Targeted analgosedation is a challenge in critically ill children, and this challenge becomes even more significant with drug shortages. Observations: Published guidelines inform the provision of analgosedation in critically ill children. This review provides insights into general approaches using these guidelines during drug shortages in Pediatric Intensive Care Units as well as strategies to optimize both pharmacological and non-pharmacological approaches in these situations. Conclusions and relevance: Considering that drug shortages are a recurrent worldwide problem, this review may guide managing these drugs in critically ill children in situations of scarcity, such as in pandemics or disasters.