Handheld miniature probe integrating diffuse optical tomography with photoacoustic imaging through a MEMS scanning mirror

• Type of Material: Article
• Authors: Hao Yang, University of Florida; Lei Xi, University of Florida; Sean Samuelson, University of Florida; Huikai Xie, University of Florida; Lily Yang, Emory University; Huabei Jiang, University of Florida
• Language: English
• Date: 2013-03-01
• Publisher: Optical Society of America
• Publication Version: Final Published Version
• Copyright Statement: © 2013 Optical Society of America.
• License: Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1364/BOE.4.000427
• Title of Journal or Parent Work: Biomedical Optics Express
• ISSN: 2156-7085
• Volume: 4
• Issue: 3
• Start Page: 427
• End Page: 432
• Grant/Funding Information: This research was supported in part by a grant from the National Institutes of Health (R21 CA161384).
• Keywords: RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING; SYSTEM; Radiology, Nuclear Medicine & Medical Imaging; Life Sciences & Biomedicine; Physical Sciences; TURBID MEDIA; Optics; IN-VIVO; Science & Technology; RECONSTRUCTION; BRAIN; BREAST-CANCER; Biochemistry & Molecular Biology; BIOCHEMICAL RESEARCH METHODS; PHANTOMS; OPTICS; Biochemical Research Methods
• Research Categories: Chemistry, Biochemistry; Engineering, Biomedical

Abstract

We describe a novel dual-modality imaging approach that integrates diffuse optical tomography (DOT) and photoacoustic imaging (PAI) through a miniaturized handheld probe based on microelectromechanical systems (MEMS) scanning mirror. We validate this dual-modal DOT/PAI approach using extensive phantom experiments, and demonstrate its application for tumor imaging using tumor-bearing mice systematically injected with targeted contrast agents.