A venomous relationship: Inflammation, the gut barrier and the STING pathway

• Type of Material: Article
• Authors: Takehiko Oami, Emory University; Craig Coopersmith, Emory University
• Language: English
• Date: 2019-04-01
• Publisher: Elsevier: Creative Commons
• Publication Version: Final Published Version
• Copyright Statement: © 2019 The Authors.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.ebiom.2019.03.055
• Title of Journal or Parent Work: EBioMedicine
• ISSN: 2352-3964
• Volume: 42
• Start Page: 36
• End Page: 37
• Grant/Funding Information: This work was supported by the National Institutes of Health (GM072808).
• Keywords: General & Internal Medicine; Medicine, Research & Experimental; Life Sciences & Biomedicine; SEPSIS; Research & Experimental Medicine; Medicine, General & Internal; Science & Technology
• Research Categories: Health Sciences, Medicine and Surgery

Abstract

Sepsis kills over 6 million people annually worldwide and leads to long-term devastating health consequences for many survivors [1]. Despite an expanding understanding of its pathophysiology, early antibiotic administration and supportive care remain the only effective therapy for sepsis. Given the high morbidity and mortality and the absence of adjuvant therapy, novel insights and potential therapeutic targets are urgently needed.