LKB1 regulated pathways in lung cancer invasion and metastasis

• Type of Material: Article
• Authors: Adam I Marcus, Emory University; Wei Zhou, Emory University
• Language: English
• Date: 2010-12
• Publisher: Lippincott, Williams & Wilkins
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2010 by the International Association for the Study of Lung Cancer
• Final Published Version (URL): http://journals.lww.com/jto/pages/articleviewer.aspx?year=2010&issue=12000&article=00003&type=abstract
• Title of Journal or Parent Work: Journal of Thoracic Oncology
• ISSN: 1556-0864
• Volume: 5
• Issue: 12
• Start Page: 1883
• End Page: 1886
• Grant/Funding Information: Dr. Marcus is supported by an American Cancer Society Research Scholar Grant (RSG-08-035-01-CSM) Dr. Marcus and Dr. Zhou are supported by a Lung Cancer Program Project (1PO1 CA116676) and are both Georgia Cancer Coalition Distinguished Scholars.
• Research Categories: Health Sciences, Oncology

Abstract

Metastasis is characterized by the ability of cancer cells to invade into adjacent tissue, intravasate into blood or lymphatic vessels, and extravasate into a distant tissue environment. Metastatic disease is primarily responsible for the low 5-year survival rate of NSCLC and therefore an understanding of the molecular mechanisms that regulate NSCLC metastasis is clearly warranted. The serine/threonine kinase and tumor suppressor LKB1 is mutated in 30% of NSCLC tumors, and recent evidence points to a prominent role in NSCLC metastasis. This review summarizes LKB1-dependent invasion pathways where compromised LKB1 function could promote NSCLC metastasis.