Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO)

• Type of Material: Conference Paper
• Authors: Ai-Ming Yu, University of California Davis; Magnus Ingelman-Sundberg, Karolinska Institutet; Nathan J. Cherrington, University of Arizona; Lauren M. Aleksunes, Rutgers State University; Ulrich M. Zanger, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology; Wen Xie, University of Pittsburgh; Hyunyoung Jeong, University of Illinois; Edward T Morgan, Emory University; Peter J. Turnbaugh, University of California San Francisco; Curtis D. Klaassen, University of Washington; Aadra P. Bhatt, University of North Carolina Chapel Hill; Matthew R. Redinbo, University of North Carolina Chapel Hill; Pengying Hao, Boston University; David J. Waxman, Boston University; Li Wang, University of Connecticut; Xiao-bo Zhong, University of Connecticut
• Language: English
• Date: 2017-03-01
• Publisher: Emory University Libraries
• Publication Version: Final Published Version
• Copyright Statement: © 2017 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences . Open Access funded by Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association
• Final Published Version (URL): http://dx.doi.org/10.1016/j.apsb.2016.12.006
• Title of Journal or Parent Work: Acta Pharmaceutica Sinica B
• Conference or Event Name: 21st International Symposium on Microsomes and Drug Oxidations (MDO)
• Volume: 7
• Issue: 2
• Start Page: 241
• End Page: 248
• Grant/Funding Information: Dr. Ai-Ming Yu׳s research was supported by grants of U01CA175315 and R01GM113888 from the U.S. National Institutes of Health (NIH); Dr. Nathan Cherrington׳s work was supported by grants of ES006694 and ES007091 from NIH; Dr. Lauren Aleksunes׳ work was supported by grants of ES021800, ES020522, and ES005022 from NIH; Dr. Ulrich Zanger׳s work was supported by the Robert Bosch Foundation, Stuttgart, Germany; Dr. Wen Xie׳s work was supported by grants of ES023438 and DK083952 from NIH; Dr. Peter Turnbaugh׳s work was supported by grant of R01HL122593 from NIH and the Searle Scholars Program, USA; Dr. Curtis D. Klaassen׳s work was supported by grant of R01ES025708 from NIH; Drs. Matthew Redinbo and Aadra Bhatt׳s work was supported by grants of CA098468 and T32DK007737 from NIH; Dr. David J. Waxman׳s work was supported by grants of R01DK33765 and R01ES024421 from NIH; Dr. Li Wang׳s work was supported by grants of R01DK104656, R01DK080440, R01ES025909, R21AA022482, and R21AA024935 from NIH, grant of 1I01BX002634 from VA Merit Award, USA, grant of No. 81572443 from National Natural Science Foundation of China, and grant of P30 DK34989 from Yale Liver Center, USA; Dr. Xiao-bo Zhong׳s work was supported by grants of R01ES019487, R01GM087367, and R01GM118367 from NIH.
• Keywords: Long non-coding RNAs; GERM-FREE MICE; Disease; PREGNANT MICE; ESTROGEN SULFOTRANSFERASE; Genetics.; EXPRESSION; SEX-DIFFERENCES; ADULT-MOUSE LIVER; Drug metabolism toxicity; ENZYMES; Science & Technology; Personalized medication; Gut microbiota; POTENTIAL ROLE; Epigenetics; Pharmacology & Pharmacy; Life Sciences & Biomedicine; BILE-ACID PATHWAYS; GROWTH-HORMONE

Abstract

Variations in drug metabolism may alter drug efficacy and cause toxicity; better understanding of the mechanisms and risks shall help to practice precision medicine. At the 21 st International Symposium on Microsomes and Drug Oxidations held in Davis, California, USA, in October 2–6, 2016, a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity, and discussed potential implications to personalized medications. A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption, distribution, metabolism, and excretion (ADME) and drug response. Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented. In addition, the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed. These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research.