Cassia auriculata: Aspects of Safety Pharmacology and Drug Interaction

• Type of Material: Article
• Authors: Amrutesh S. Puranik, University of Pune; Ganesh Halade, University of Texas; Sandeep Kumar, Emory University; Ranjan Mogre, Applied Biotech; Kishori Apte, National Toxicology Center; Ashok D. B. Vaidya, Advanced Centre of Reverse Pharmacology; Bhushan Patwardhan, University of Pune
• Language: English
• Date: 2011-05-03
• Publisher: Hindawi Publishing Corporation
• Publication Version: Final Published Version
• Copyright Statement: Copyright 2011 Amrutesh S. Puranik et al.
• License: Creative Commons Attribution 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1093/ecam/nep237
• Title of Journal or Parent Work: Evidence-Based Complementary and Alternative Medicine
• ISSN: 1741-427X
• Volume: 2011
• Start Page: 915240
• End Page: 915240
• Grant/Funding Information: Supercritical extracts were prepared at gratis by Vedic Supercriticals & Biotechnologies (I) Pvt. Ltd, Pune, under supervision (R. Mogre and A. S. Puranik).; Authors thank The Lady Tata Memorial Trust, Mumbai, India, (http://www.dorabjitatatrust.org/) that provided part funding through contingency for this work; remaining funding has come through respective institutions where the work was carried out.
• Keywords: NATURAL-PRODUCT; Science & Technology; METABOLISM; SUPERCRITICAL-FLUID EXTRACTION; LIQUID-CHROMATOGRAPHY; DISCOVERY; OXIDATIVE STRESS; ETHNOPHARMACOLOGY; Integrative & Complementary Medicine; Life Sciences & Biomedicine; HERBAL MEDICINES; STREPTOZOTOCIN; DIABETIC-RATS
• Research Categories: Health Sciences, Pharmacology; Health Sciences, Toxicology; Health Sciences, Pharmacy

Abstract

Safety pharmacology studies help in identifying preclinical adverse drug reactions. We carried out routine safety pharmacology with focus on cardiovascular variables and pharmacokinetic herb-drug interaction studies on rats fed with standardized traditional hydro-alcoholic extract and technology-based supercritical extract of Cassia auriculata for 12 weeks. Our studies indicate that both these extracts are pharmacologically safe and did not show any significant adverse reactions at the tested doses. The traditional hydro-alcoholic extract did not show any significant effect on pharmacokinetics; however, the technology-based supercritical extract caused a significant reduction in absorption of metformin. Our results indicate the need to include pharmacokinetic herb-drug interaction studies as evidence for safety especially for technology-based extracts.