Minimally invasive protein delivery with rapidly dissolving polymer microneedles

• Type of Material: Article
• Authors: Sean P Sullivan, Emory University; Niren Murthy, Emory University; Mark R. Prausnitz, Emory University
• Language: English
• Date: 2008-03-05
• Publisher: Wiley: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: Copyright © 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
• Final Published Version (URL): http://dx.doi.org/10.1002/adma.200701205
• Title of Journal or Parent Work: Advanced Materials
• ISSN: 0935-9648
• Volume: 20
• Issue: 5
• Start Page: 933
• End Page: +
• Grant/Funding Information: This work was carried out at the Institute for Bioengineering and Bioscience and the Center for Drug Design, Development and Delivery at Georgia Tech.; This work was supported in part by the Southeast Regional Center of Excellence for Emerging Infections and Biodefense; and the National Institutes of Health.
• Keywords: IMMUNIZATION; SKIN; Technology; Materials Science, Multidisciplinary; Chemistry, Multidisciplinary; Physics; Science & Technology - Other Topics; Physical Sciences; TRANSDERMAL DRUG-DELIVERY; Physics, Applied; Physics, Condensed Matter; Chemistry; NEEDLES; INSULIN; Nanoscience & Nanotechnology; Chemistry, Physical; FABRICATION; Materials Science; Science & Technology
• Research Categories: Engineering, Biomedical

Abstract

A novel hybrid delivery approach to achieve the delivery efficacy of injections, the safety, and patient compliance of the patch involved the designing and synthesis of the of rapidly dissolving polymer needles of micrometer dimensions for painless, self-administered delivery of the biomolecules, and especially for minimally invasive protein delivery. The researchers to achieve the goal encapsulated red-fluorescent bovine serum albumin within PVP polymer microneedles and delivered to procine skin. The fabrication developed is based on room-temperature in-situ polymerization, and also includes the details from the mechanical, encapsulation, and delivery properties of the resulting microneedles for the delivery of biomolecules to the skin. The development of microneedles has used the master structures made of a polymeric photoresist epoxy (SU-8) by a photolithography method, and then used three master structures to create reverse molds from polydimethylsiloxane (PDMS).