Nup98-Homeodomain Fusions Interact with Endogenous Nup98 during Interphase and Localize to Kinetochores and Chromosome Arms during Mitosis

• Type of Material: Article
• Authors: Songli Xu, Emory University; Maureen Powers, Emory University
• Language: English
• Date: 2010-05-01
• Publisher: American Society for Cell Biology
• Publication Version: Final Published Version
• Copyright Statement: © 2010 by The American Society for Cell Biology
• Final Published Version (URL): http://www.molbiolcell.org/content/21/9/1585
• Title of Journal or Parent Work: Molecular Biology of the Cell
• ISSN: 1059-1524
• Volume: 21
• Issue: 9
• Start Page: 1585
• End Page: 1596
• Grant/Funding Information: National Institutes of Health Grant GM-59975 to M.A.P. and by a grant from the Emory University Research Committee to M.A.P.
• Research Categories: Biology, Cell

Abstract

Fusion proteins containing the FG/GLFG repeats of Nup98 joined to a homeodomain are implicated in leukemias. We find expression of these proteins leads to mislocalization of endogenous intranuclear Nup98. During mitosis, fusions concentrate at kinetochores and chromosomes. These findings suggest new possible contributions of Nup98 fusions to leukemogenesis.