Striatal Oscillations in Parkinsonian Non-Human Primates

• Type of Material: Article
• Authors: Arun Singh, Emory University; Stella Papa, Emory University
• Language: English
• Date: 2020-11-21
• Publisher: PERGAMON-ELSEVIER SCIENCE LTD
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.neuroscience.2020.09.004
• Title of Journal or Parent Work: NEUROSCIENCE
• Volume: 449
• Start Page: 116
• End Page: 122
• Grant/Funding Information: This work was supported by NIH grants NS045962, NS073994, RR000165 and OD011132 (S.M.P).
• Keywords: MOVEMENT; BETA-OSCILLATIONS; SUBTHALAMIC NUCLEUS; CEREBRAL-CORTEX; local field potentials; Life Sciences & Biomedicine; BRAIN; NETWORK; PROJECTION NEURONS; Parkinson's disease; DOPAMINE; ACTIVITY PATTERNS; Neurosciences; Science & Technology; Neurosciences & Neurology; non-human primates; striatal projection neurons; dopamine; MEDIUM SPINY NEURONS

Abstract

Dopamine loss in Parkinson's disease (PD) is associated with abnormal oscillatory activity in the cortico-basal ganglia network. However, the oscillatory pattern of striatal neurons in PD remains poorly defined. Here, we analyzed the local field potentials in one untreated and five MPTP-treated non-human primates (NHP) with chronic, advanced parkinsonism. Oscillatory activities in the alpha (8–13 Hz) and low-beta (13–20 Hz) frequency bands were found in the striatum similarly to the motor cortex and globus pallidus of the NHP model of PD. Both alpha and low-beta frequency band oscillations of the striatum were highly coherent with the cortical and pallidal oscillations, confirming the presence of abnormal 8–20 Hz oscillatory activity in the cortico-basal ganglia network in parkinsonian NHPs. The reversal of parkinsonism induced by acute levodopa administration was associated with reduced 8–20 Hz oscillations in the striatum. These findings indicate that pathological oscillations at alpha and low-beta bands are also present in the striatum concordant with basal ganglia network changes in the primate model of PD.