A fluorescent probe for fast and quantitative detection of hydrogen sulfide in blood

• Type of Material: Article
• Authors: Hanjing Peng, Georgia State University; Yunfeng Cheng, Georgia State University; Chaofeng Dai, Georgia State University; Adrienne King, Emory University; Benjamin L. Predmore, Emory University; David J. Lefer, Emory University; Binghe Wang, Georgia State University
• Language: English
• Date: 2011-10-04
• Publisher: Wiley: 12 months
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
• Final Published Version (URL): http://dx.doi.org/10.1002/anie.201104236
• Title of Journal or Parent Work: Angewandte Chemie International Edition
• ISSN: 1433-7851
• Volume: 50
• Issue: 41
• Start Page: 9672
• End Page: 9675
• Grant/Funding Information: We gratefully acknowledge the financial support of this work by the Molecular Basis of Disease Program at Georgia State University through fellowships to H.P. and Y.C., the NIH (GM084933) grant to B.W.; NIH (5R01HL092141-03 and 5R01HL093579-02) grant to D.J.L and to A.L.K (NIH 3K12GM000680-10S1 FIRST Fellowship Program) as well as funds from the Carlyle Fraser Heart Center of Emory University Hospital Midtown.
• Keywords: Animals; Indicators and Reagents; Dansyl Compounds; Molecular Structure; Hydrogen Sulfide; Mice, Inbred C57BL; Mice; Fluorescent Dyes
• Research Categories: Chemistry, Biochemistry; Health Sciences, Medicine and Surgery

Abstract

The dose makes the poison: Hydrogen sulfide is an important gasotransmitter for which rapid detection agents are needed. A hydrogen sulfide probe, which allows for fast (within seconds), selective, and quantitative detection in buffer solution, serum, and whole blood is designed, synthesized, and used for detection of hydrogen sulfide (see picture).