Publication

Editorial: NK cell defects: diagnosis and treatment

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Last modified
  • 06/25/2025
Type of Material
Authors
    Snehal Shabrish, Tata Memorial CentreShanmuganathan Chandrakasan, Emory UniversityManisha Madkaikar, National Institute of Immunohaematology
Language
  • English
Date
  • 2023-10-31
Publisher
  • Frontiers
Publication Version
Copyright Statement
  • © 2023 Shabrish, Chandrakasan and Madkaikar
License
Final Published Version (URL)
Title of Journal or Parent Work
Volume
  • 14
Start Page
  • 1323793
Grant/Funding Information
  • The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Abstract
  • Natural Killer (NK) cells form an integral component of the immune response, especially against virally infected cells and cancer cells (1). They have gained diagnostic and prognostic significance in the last few decades with increasing literature portraying their role in inflammatory disease pathology and therapy (2, 3). However, even though these cells have importance in research set-up, this significance has not yet reached routine clinical set-up. Various inherited genetic defects, pathological conditions, and therapies are known to have immunosuppressive effects on NK cells, causing NK cell defects (4, 5). However, in many of these cases, the mechanism remains unclear. This could be attributed to the lack of studies focusing on NK cell immune biology, the influence of varied pathological conditions on its immune phenotype and functions; and its impact on outcome. In the future, translation of this knowledge from “bench-to-bedside” will definitely contribute to better diagnosis and therapeutics in multiple pathological conditions. Thus, the main focus of this Research Topic was to explore recent advances in understanding NK cell defects, their diagnosis, and their treatment. In total, after being peer-review, 4 manuscripts, composed of 3 research articles and 1 review article from 28 researchers were successfully accepted for publication.
Author Notes
Keywords
Research Categories
  • Health Sciences, Immunology
  • Biology, Molecular
  • Biology, Cell

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