Anticancer and Antitumor Potential of Fucoidan and Fucoxanthin, Two Main Metabolites Isolated from Brown Algae

• Type of Material: Article
• Authors: Soheil Zorofchian Moghadamtousi, University of Malaya; Hamed Karimian, University of Malaya; Ramin Khanabdali, University of Malaya; Mahboubeh Razavi, University of Malaya; Mohammad Firoozinia, University of Malaya; Keivan Zandi, Emory University; Habsah Abdul Kadir, University of Malaya
• Language: English
• Date: 2014-01-01
• Publisher: Hindawi Publishing Corporation
• Publication Version: Final Published Version
• Copyright Statement: © 2014 Soheil Zorofchian Moghadamtousi et al.
• License: Creative Commons Attribution 3.0 Unported
• Final Published Version (URL): http://dx.doi.org/10.1155/2014/768323
• Title of Journal or Parent Work: Scientific World Journal
• ISSN: 2356-6140
• Volume: 2014
• Start Page: 768323
• End Page: 768323
• Grant/Funding Information: The authors would like to thank the University of Malaya for providing the research Grant (RP001-2012C) and the High Impact Research (J-21010-73848) and (F000002-21001).
• Keywords: BRONCHOPULMONARY CARCINOMA LINE; Multidisciplinary Sciences; PROSTATE-CANCER CELLS; ANTIPROLIFERATIVE ACTIVITY; DEACETYLATED PRODUCT; Science & Technology - Other Topics; IN-VITRO; Science & Technology; DOWN-REGULATION; SIGNAL PATHWAY; SULFATED POLYSACCHARIDE; MARINE-ALGAE; UNDARIA-PINNATIFIDA
• Research Categories: Health Sciences, Pharmacy; Health Sciences, Epidemiology

Abstract

Seaweed is one of the largest producers of biomass in marine environment and is a rich arsenal of active metabolites and functional ingredients with valuable beneficial health effects. Being a staple part of Asian cuisine, investigations on the crude extracts of Phaeophyceae or brown algae revealed marked antitumor activity, eliciting a variety of research to determine the active ingredients involved in this potential. The sulfated polysaccharide of fucoidan and carotenoid of fucoxanthin were found to be the most important active metabolites of brown algae as potential chemotherapeutic or chemopreventive agents. This review strives to provide detailed account of all current knowledge on the anticancer and antitumor activity of fucoidan and fucoxanthin as the two major metabolites isolated from brown algae.