Clinical Imaging-Derived Metrics of Corticospinal Tract Structural Integrity Are Associated With Post-stroke Motor Outcomes: A Retrospective Study

• Type of Material: Article
• Authors: Mary Alice Saltao da Silva, Emory University; Nathan A Baune, Emory University; Samir Belagaje, Emory University; Michael Borich, Emory University
• Language: English
• Date: 2022-02-17
• Publisher: FRONTIERS MEDIA SA
• Publication Version: Final Published Version
• Copyright Statement: © 2022 Saltão da Silva, Baune, Belagaje and Borich.
• License: Creative Commons Attribution 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.3389/fneur.2022.804133
• Title of Journal or Parent Work: FRONTIERS IN NEUROLOGY
• Volume: 13
• Start Page: 804133
• End Page: 804133
• Grant/Funding Information: MS was supported by a Stroke Research Fellowship from the NIH StrokeNet.
• Keywords: UPPER-LIMB RECOVERY; LESION LOAD; STROKE; Neurosciences; motor recovery; ADULT NORMS; premotor and motor cortex; Life Sciences & Biomedicine; FRONTAL-LOBE; Neurosciences & Neurology; clinical MRI; Clinical Neurology; outcome prediction; Science & Technology; IMPAIRMENT; corticospinal tract (CST); stroke; AREAS; PREDICTION; RELIABILITY; PREMOTOR CORTEX
• Research Categories: Biology, General; Health Sciences, Rehabilitation and Therapy

Abstract

Objective: The primary objective of this study was to retrospectively investigate associations between clinical magnetic resonance imaging-based (MRI) metrics of corticospinal tract (CST) status and paretic upper extremity (PUE) motor recovery in patients that completed acute inpatient rehabilitation (AR) post-stroke. Methods: We conducted a longitudinal chart review of patients post-stroke who received care in the Emory University Hospital system during acute hospitalization, AR, and outpatient therapy. We extracted demographic information, stroke characteristics, and longitudinal documentation of post-stroke motor function from institutional electronic medical records. Serial assessments of paretic shoulder abduction and finger extension were estimated (E-SAFE) and an estimated Action Research Arm Test (E-ARAT) score was used to quantify 3-month PUE motor function outcome. Clinically-diagnostic MRI were used to create lesion masks that were spatially normalized and overlaid onto a white matter tract atlas delineating CST contributions emanating from six cortical seed regions to obtain the percentage of CST lesion overlap. Metric associations were investigated with correlation and cluster analyses, Kruskal-Wallis tests, classification and regression tree analysis. Results: Thirty-four patients met study eligibility criteria. All CST overlap percentages were correlated with E-ARAT however, ventral premotor tract (PMv) overlap was the only tract that remained significantly correlated after multiple comparisons adjustment. Lesion overlap percentage in CST contributions from all seed regions was significantly different between outcome categories. Using MRI metrics alone, dorsal premotor (PMd) and PMv tracts classified recovery outcome category with 79.4% accuracy. When clinical and MRI metrics were combined, AR E-SAFE, patient age, and overall CST lesion overlap classified patients with 88.2% accuracy. Conclusions: Study findings revealed clinical MRI-derived CST lesion overlap was associated with PUE motor outcome post-stroke and that cortical projections within the CST, particularly those emanating from non-M1 cortical areas, prominently ventral premotor (PMv) and dorsal premotor (PMd) cortices, distinguished between PUE outcome groups. Exploratory predictive models using clinical MRI metrics, either alone or in combination with clinical measures, were able to accurately identify recovery outcome category for the study cohort during both the acute and early subacute phases of post-stroke recovery. Prospective studies are recommended to determine the predictive utility of including clinical imaging-based biomarkers of white matter tract structural integrity in predictive models of post-stroke recovery.