A Microbiome Foundation for the Study of Crohn's Disease

• Type of Material: Article
• Authors: Dirk Gevers, Janssen Human Microbiome Institute at Janssen Research and Development LLC; Subra Kugathasan, Emory University; Dan Knights, University of Minnesota; Aleksandar D. Kostic, Joslin Diabetes Center; Rob Knight, University of Colorado; Ramnik J. Xavier, Broad Institute of MIT and Harvard
• Language: English
• Date: 2017-03-08
• Publisher: Elsevier (Cell Press): 12 month embargo
• Publication Version: Author Accepted Manuscript (After Peer Review)
• Copyright Statement: Copyright @ 2014, Elsevier
• License: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International
• Final Published Version (URL): http://dx.doi.org/10.1016/j.chom.2017.02.012
• Title of Journal or Parent Work: Cell Host and Microbe
• ISSN: 1931-3128
• Volume: 21
• Issue: 3
• Start Page: 301
• End Page: 304
• Keywords: Science & Technology; Parasitology; Virology; ORAL MICROBIOTA; DYSBIOSIS; Life Sciences & Biomedicine; Microbiology; INFLAMMATORY-BOWEL-DISEASE
• Research Categories: Health Sciences, Immunology; Health Sciences, Nutrition; Biology, Microbiology

Abstract

Our 2014 study published in Cell Host & Microbe, "The Treatment-Naive Microbiome in New-Onset Crohn's Disease," was designed to improve our understanding of the microbiome's role in Crohn's disease by studying a unique, well-suited cohort and sample set. This commentary provides a hindsight perspective of this original study as well as future outlook.