Publication

MANF: A New Player in the Control of Energy Homeostasis, and Beyond.

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Last modified
  • 05/15/2025
Type of Material
Authors
    Su Yang, Emory UniversityShihua Li, Emory UniversityXiao-Jiang Li, Emory University
Language
  • English
Date
  • 2018-11-29
Publisher
  • Frontiers Media
Publication Version
Copyright Statement
  • © 2018 Yang, Li and Li.
License
Final Published Version (URL)
Title of Journal or Parent Work
ISSN
  • 1664-042X
Volume
  • 9
Start Page
  • 1725
End Page
  • 1725
Grant/Funding Information
  • The work was supported by NIH grants (NS102913 to X-JL and NS095279 to SL).
Abstract
  • All human behaviors, including the control of energy homeostasis, are ultimately mediated by neuronal activities in the brain. Neurotrophic factors represent a protein family that plays important roles in regulating neuronal development, function, and survival. It has been well established that canonical neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF), play important roles in the central regulation of energy homeostasis. Recently, a class of non-canonical neurotrophic factors, represented by mesencephalic astrocyte-derived neurotrophic factor (MANF), has been discovered. MANF is structurally and functionally distinct from those canonical neurotrophic factors, hence raising the issue of MANF being non-canonical. Nonetheless, emerging evidence suggests that MANF is critically involved in many neuronal activities. Here, we review our current understanding about the functions of MANF in the brain, with a primary focus on the control of energy homeostasis.
Author Notes
Keywords
Research Categories
  • Biology, Neuroscience
  • Biology, Genetics

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